英文名稱 ANKRD6
中文名稱 錨蛋白重復域6抗體
別    名 ANKRD 6; ankyrin repeat domain 6; ANKR6_HUMAN; Ankyrin repeat domain-containing protein 6; Diversin.
錨蛋白重復域6抗體說 明 書 0.1ml  0.2ml  
研究領域 細胞生物  神經(jīng)生物學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ANKRD6/Diversin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Diversin, also known as ANKRD6 (ankyrin repeat domain 6), is a 727 amino acid protein that contains eight ankyrin repeats and belongs to the ankyrin repeat domain protein family. Members of the ankyrin repeat domain family facilitate protein-protein interactions and function as adaptors of signaling pathways. Expressed in a developmentally-regulated manner and at highest levels in the brain, Diversin is believed to play a role in brain development. Via its ankyrin repeats, Diversin can directly interact with Dvl (dishevelled), an interaction that is essential for the activation of noncanonical Wnt signaling. In addition, Diversin contains a C-terminal domain that binds Axin/Conductin and a casein kinase-binding domain in its central region that specifically binds casein kinase Ié. Through the action of these additional domains, Diversin may also facilitate canonical Wnt signaling. Due to alternative splicing events, three Diversin isoforms exist.

Function:
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.

Subunit:
Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.

Similarity:
Contains 8 ANK repeats.

Database links:

Entrez Gene: 22881 Human

Omim: 610583 Human

SwissProt: Q9Y2G4 Human

Unigene: 702213 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.xym-2156M HER2 receptor(1A4) HER2受體單克隆抗體
xy-6228R HRG beta 1乳腺癌細胞分化因子P45抗體 Heregulinβ
xy-6615R Hepatic lipase肝脂酶抗體
xy-5387R phospho-HDAC1 (Ser423)磷酸化組蛋白去乙酰化酶1抗體
xy-6107R HLTF解旋酶樣轉錄因子抗體
xy-5070R HMGCS2三羥基*基輔酶A合成酶2抗體
xy-2355R HLA Class 1 ABC人類白細胞抗原A抗體
xy-3856R HSD17B2羥類固醇脫氫酶17β2抗體
xy-3855R HSD17B1羥類固醇脫氫酶17β-HSD抗體
xym-2741M Hepatocyte(2H5)人肝細胞單克隆抗體/肝細胞特異性抗原抗體
xym-0287M His tag(2D5)小鼠抗聚組氨酸單克隆抗體
xy-8870R Hepcidin-25鐵調節(jié)蛋白/鐵調素抗體
xy-7233R HSJ1熱休克蛋白J1抗體
xy-3767R Hes5發(fā)狀分裂相關增強子-5抗體
xy-3181R Phospho-HSP90 alpha (Thr5 + Thr7)磷酸化熱休克蛋白90α抗體
xy-3185R Phospho-Histone H2A.X (Ser139)磷酸化組蛋白H2AX抗體
xy-3187R Phospho-Histone H3 (Ser28)磷酸化組蛋白H3抗體
xy-3188R Phospho-Histone H3 (Thr11)磷酸化組蛋白H3抗體
xy-3189R Phospho-Histone H3 (Thr3)磷酸化組蛋白H3抗體
xy-2810R HDAC5組蛋白去乙酰化酶5抗體
xy-2284R H5N1 HemagglutininA型流感病毒H5N1凝集素
xy-2274R HCMV UL49人巨細胞病毒UL49蛋白抗體
xy-8617R HNF1 beta肝細胞核因子1β/HNF-1β抗體