英文名稱 Bag1
中文名稱 抑凋亡基因bag1抗體
別    名 Bag 1; Bag-1; BAG family molecular chaperone regulator 1; BCL 2 Associated Athanogene 1; BCL 2 associated athanogene; BCL 2 binding athanogene 1; BCL2 associated athanogene 1; BCL2 associated athanogene; Glucocorticoid receptor-associated protein RAP46; HAP1 antibody Haptoglobin; RAP 46; RAP46.
抑凋亡基因bag1抗體
   
說(shuō) 明 書(shū) 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Bag1/RAP46
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq].
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.

Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.

Subunit:
Contains 1 BAG domain. Contains 1 ubiquitin-like domain.

Subcellular Location:
Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus and Cytoplasm. Nucleus. Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.

Tissue Specificity:
Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines.

Database links:

Entrez Gene: 573 Human

Entrez Gene: 12017 Mouse

Entrez Gene: 297994 Rat

Omim: 601497 Human

SwissProt: Q99933 Human

SwissProt: Q60739 Mouse
xy-15282R C7orf727號(hào)染色體開(kāi)放閱讀框72抗體
xy-8131R CCDC42卷曲螺旋結(jié)構(gòu)域蛋白42抗體
xy-8134R CCDC47卷曲螺旋結(jié)構(gòu)域蛋白47抗體
xy-8132R CCDC43卷曲螺旋結(jié)構(gòu)域蛋白43抗體
xy-8133R CCDC46卷曲螺旋結(jié)構(gòu)域蛋白46抗體
xy-8137R CCDC63卷曲螺旋結(jié)構(gòu)域蛋白63抗體
xy-8135R CCDC54卷曲螺旋結(jié)構(gòu)域蛋白54抗體
xy-8136R CCDC61卷曲螺旋結(jié)構(gòu)域蛋白61抗體
xy-8138R CCDC8卷曲螺旋結(jié)構(gòu)域蛋白8抗體
xy-7906R CERK神經(jīng)酰胺激酶CERK抗體
xy-7907R CLK2細(xì)胞分裂周期樣激酶2抗體
xy-7908R CLK3細(xì)胞分裂周期樣激酶3抗體
xy-9640R C17orf4917號(hào)染色體開(kāi)放閱讀框49抗體
xy-9641R C17orf5317號(hào)染色體開(kāi)放閱讀框53抗體
xy-9642R C17orf5717號(hào)染色體開(kāi)放閱讀框57抗體
xy-9643R C17orf6417號(hào)染色體開(kāi)放閱讀框64抗體
xy-9644R C17orf6617號(hào)染色體開(kāi)放閱讀框66抗體
xy-9645R C17orf7417號(hào)染色體開(kāi)放閱讀框74抗體
xy-9646R C17orf7517號(hào)染色體開(kāi)放閱讀框75抗體
xy-9647R C17orf7717號(hào)染色體開(kāi)放閱讀框77抗體
xy-9648R C17orf7817號(hào)染色體開(kāi)放閱讀框78抗體

SwissProt: B0K019 Rat

Unigene: 377484 Human

Unigene: 688 Mouse

Unigene: 16320 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.