英文名稱 CD108
中文名稱 軸突生長(zhǎng)因子CD108抗體
別    名 semaphorin 7A; CD 108; CD108; CD108 antigen; CDw108; H Sema K1; H Sema L; JMH; JMH blood group antigen; John Milton Hagen blood group H Sema K1; John Milton Hargen human blood group Ag; MGC126692; MGC126696; Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A; Sema L; Sema7a; SEMAK1; SEMAL; Semaphorin 7A GPI membrane anchor; Semaphorin K1; Semaphorin L; Semaphorin7a; SEM7A_HUMAN.
 軸突生長(zhǎng)因子CD108抗體
  
說(shuō) 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
細(xì)胞定位 細(xì)胞膜 細(xì)胞外基質(zhì) 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sema7A
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
產(chǎn)品介紹 background:
Semaphorin 7a is required for central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Semaphorin 7a is also involved in modulating immune function. Semaphorin 7a expression is highest in the brain and increases in late embryonic and postnatal stages. The Semaphorins constitute a large family of secreted and membrane-tethered cell signaling molecules. They have functions in neural development, immunology, cardiac growth, vascular development, lung morphogenesis and axial bone patterning. Semaphorins are defined by the presence of a conserved Sema domain at the N-terminus. These proteins can be classified into eight classes depending on their structure and species origin. Classes 3 through 7 are found in vertebrates; class 3 are secreted, class 7 are GPI-anchored, and class 4 through 6 are transmembrane proteins.

Function:
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

Subunit:
Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.

Tissue Specificity:
Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney.

Similarity:
Belongs to the semaphorin family.

Gene ID:
8482

Database links:

Entrez Gene: 8482 Human

Entrez Gene: 20361 Mouse

Entrez Gene: 315711 Rat

Omim: 607961 Human

SwissProt: O75326 Human

SwissProt: Q9QUR8 Mouse

Unigene: 24640 Human

Unigene: 335187 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
xy-10516R Calcitonin receptor降鈣素受體抗體
xy-10428R C2a補(bǔ)體C2a鏈多肽抗體
xy-10340R CD80CD80抗體
xy-10358R CD19CD19抗體
xy-15512R CCL26C-C元件趨化因子26抗體
xy-15200R C5orf225號(hào)染色體開(kāi)放閱讀框22抗體
xy-15511R CLCA4鈣激活氯離子通道4蛋白抗體
xy-10409R CCL26 Signal peptide嗜酸粒細(xì)胞趨化蛋白3抗體
xy-15513R CCL26嗜酸粒細(xì)胞趨化蛋白3抗體
xy-10410R chemerin趨化素抗體
xy-15211R C5orf55 5號(hào)染色體開(kāi)放閱讀框55抗體
xy-2555R CXCR7細(xì)胞表面趨化因子受體7抗體
xy-2562R COX7A2細(xì)胞色素c氧化酶7A2抗體
xy-8873R CD36CD36抗體
xy-10161R CYP11B2醛固酮合成酶CYP11B2抗體
xy-15259R C7orf167號(hào)染色體開(kāi)放閱讀框16抗體
xy-9769R C10orf6210號(hào)染色體開(kāi)放閱讀框62抗體
xy-12423R CAPRIN2胃癌多藥耐藥相關(guān)蛋白
xy-12427R Caseine Kinase 1 alpha酪蛋白激酶casein kinase Iα抗體
xy-12428R phospho-Caseine Kinase 1 alpha(Tyr294)磷酸化酪蛋白激酶casein kinase Iα抗體
xy-12429R phospho-Caseine Kinase 1 alpha (Thr1194)磷酸化酪蛋白激酶casein kinase Iα抗體
xy-12445R Actin Regulatory Protein CAPG肌動(dòng)蛋白調(diào)節(jié)蛋白CAPG抗體
xy-7158R Collagen IⅠ型膠原/1型膠原a1抗體
xy-7322R Collagen IIIⅢ型膠原蛋白/膠原蛋白3/3型膠原蛋白抗體
xy-12187R CD96CD96抗體
xy-13824R CECR2貓眼綜合征染色體候選基因2抗體
xy-15024R C1orf1461號(hào)染色體開(kāi)放閱讀框146抗體
xy-15028R C1orf150 1號(hào)染色體開(kāi)放閱讀框150抗體