Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (C-Term) 抗體

抗原
Actin Filament Associated Protein 1-Like 2 (AFAP1L2)
別名 KIAA1914, XB130, AU041783, C86904, mKIAA1914, RGD1310668
抗原表位
其他選擇 C-Term
C-Term(10),N-Term (3),AA 1-241 (1),AA 554-818 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(32),Murine (24),Rat ((Rattus)) (24)
宿主
其他選擇 Rabbit
Rabbit(32)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Alexa Fluor 350(1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Biotin (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),FITC (1),HRP (1)
應(yīng)用范圍
其他選擇 ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Western Blotting (WB)(23),ELISA (12),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (IHC) (8),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8),Enzyme Immunoassay (EIA) (2),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2),Flow Cytometry (FACS) (1)
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時(shí)間 24至29個(gè)工作日

Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (C-Term) 抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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免疫原 The immunogen for anti-AFAP1L2 antibody: antibody was raised against a 15 amino acid peptide near the carboxy terminus of human AFAP1L2.
預(yù)測反應(yīng) Human Mouse Rat
產(chǎn)品特性 Afap1l2, Also Known As Xb130, Is Structurally Similar To Actin-Filament-Associated Protein (AFAP), Containing Several Sh2- And Sh3-Binding Motifs, Two Pleckstrin Homology Domains, A Coiled-Coil Region, And Many Potential Phosphorylation Sites. It Interacts With And Is Phosphorylated By C-Src Tyrosine Kinase. Suppression Of Afap1l2 Via Sirna Reduced Src Activity, Il-8 Production, Egf-Induced Phosphorylation Of Akt And Gsk3beta, And Altered Cell Cycles In Human Lung Epithelial Cells Suggesting That Afap1l2 Plays A Role As An Adaptor In The Regulation Of Src Signal Transduction And Multiple Cellular Functions. Recent Experiments Have Shown That Afap1l2 Is Highly Expressed In Thyroid And Is The Substrate Ret/Ptc Kinase, A Thyroid-Specific Kinase That Plays A Pathogenic Role In Papillary Thyroid Cancer. Down-Regulation Of Afap1l2 In These Cancer Cells Reduced Akt Activity, Inhibiting Cell-Cycle Progression And Cancer Cell Survival In Suspension, Indicating That Afap1l2 May Be A Valuable Target In Thyroid Cancer Therapy. At Least Four Isoforms Of Afap1l2 Are Known To Exist.
純化方法 Affinity chromatography purified via peptide column

Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (C-Term) 抗體目標(biāo)詳細(xì)情況

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別名 AFAP1L2
背景 Actin Filament Associated Protein 1-Like 2 Protein

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Actin Filament Associated Protein 1-Like 2 (AFAP1L2) (C-Term) 抗體使用細(xì)節(jié)

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應(yīng)用備注 AFAP1 L2 antibody can be used for detection of AFAP1 L2 by Western blot at 1 - 2?μg/mL
限制 For Research Use only

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注意事項(xiàng) As with all antibodies care should be taken to avoid repeated freeze thaw cycles.
Antibodies should not be exposed to prolonged high temperatures.
儲存條件 4 °C
儲存方法 AFAP1L2 antibody can be stored at 4 °C
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