MYD88抗體

抗原
Myeloid Differentiation Primary Response Gene (88) (MYD88)
別名 XMyD88, myd88d, MGC84928, CG2078, DMMYD88, DmMyD88, DmMyd88, DmelCG2078, EP(2)2535, Kra, LD20892, MYD88, MyD88, Myd88F, dMyD88, dMyd88, kra, myd88, zgc:103541, GB12344, NV10640, irak-2, MYD88D
抗原表位
其他選擇 N-Term
Internal Region(16),C-Term (15),AA 233-248 (12),AA 279-296 (9),Middle Region (8),AA 176-280 (6),AA 1-296 (4),N-Term (4),AA 136-164 (2),AA 50-100 (2),AA 1-260 (1),AA 1-309 (1),AA 143-172 (1),AA 171-220 (1),AA 205-265 (1),AA 73-296 (1),Center (1),Val220 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(139),Murine (64),Rat ((Rattus)) (40),Zebrafish (4),Monkey (3),Sponges (Suberites domuncula) (3),Dog (Canine) (2),Chicken (1),Chimpanzee (1),Bovine (1),Pig (Porcine) (1)
宿主
其他選擇 Rabbit
Rabbit(118),Mouse (31),Goat (5)
克隆類型
多克隆
標記
其他選擇 非結合性
Biotin(3),FITC (3),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
應用范圍
其他選擇 Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB), Enzyme Immunoassay (EIA), Western Blotting (WB)
Western Blotting (WB)(136),ELISA (45),Immunohistochemistry (IHC) (43),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (23),Flow Cytometry (FACS) (16),Immunofluorescence (IF) (13),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Enzyme Immunoassay (EIA) (8),Immunocytochemistry (ICC) (8),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (6),Immunoassay (IA) (5),Immunohistochemistry (Frozen Sections) (IHC (fro)) (3),Immunoprecipitation (IP) (3)
[Pubmed] 3 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

MYD88抗體

產品細節(jié)

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產品細節(jié)

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免疫原 Synthetic peptide was selected from the unique amino-terminal end of MYD88
特異性 This antibody labels MyD88 at 59 kDa.
交叉反應 （詳細） Species reactivity (tested):Human, mouse, rat
純化方法 Affinity chromatography

目標詳細情況

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目標詳細情況

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別名 MYD88
背景 The mammalian host defense system is essentially regulated by Toll-like receptor (TLR) family. Toll-like receptors (TLRs) play an important role in recognition of microbial components and induction of innate immunity. At least 10 TLRs have been identified and cloned in mammalian cells which recognize molecular products/signals from all the major classes of pathogens. The Toll signaling to NF-Kb starts form conserved Toll-IL-1-resistance (TIR) domain, which mediated the coupling of TIR adaptor molecules (MyD88, Mal, TICAM and TRAM). Most of the TLRs are dependent on the expression of adapter molecules MyD88 for all their function, the TL3 and TLR 4 are unique in their ability to mediate both MyD88-dependent and independent reposes (1). The MyD88 independent pathway involves induction of a DC maturation and induction of type 1 interferon (IFN-B). Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to 'death-domains', is rapidly up-regulated during differentiation of the myeloleukemic cell line M1. The murine MyD88 is 53 amino acids larger than human MyD88 and maps to chromosome 3p21.3-p22. The over expression of death region in MyD88 lead to transcriptional activation of IL-8 promoter. The microbial components trigger the activation of two downstream signaling pathways of TLRs, MyD88- and/or TRIF-dependent pathways leading to activation of NF-kappaB. The MyD88 transduces a core set of Toll-like receptor (TLR)-induced signals, microbial-induced host responses are divided broadly into the MyD88-dependent and MyD88-independent pathways. The specific pathogen induced early host responses are generally mediated by MyD88 dependent pathways. Inhaled endotoxins induce an acute inflammatory response in the airways mediated through Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88). The endotoxin-induced acute bronchoconstriction, vascular damage resulting in protein leak, Th1 cytokine and chemokine secretion and neutrophil recruitment in the airways are abrogated in mice deficient for either TIRAP or MyD88, but not in TRIF deficient mice (2). The bronchoconstriction and acute inflammatory lung pathology mediated by TLR-4 to inhaled endotoxins critically dependent on the expression and co-operative role of adaptor proteins, TIRAP and MyD88 (3). The MyD88 mediated post-TLR signaling is also involved in a number of allergents and endotoxins.Synonyms: Myeloid differentiation primary response protein MyD88
基因ID 4615
NCBI Accession NP_002459
UniProt Q99836

使用細節(jié)

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使用細節(jié)

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應用備注 Immunohistochemistry on frozen sections. Dot blot: 1: 20,000. ELISA: 1: 20,000. Western blot: 1: 500-1: 750.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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濃度 0.68 - 0.98 mg/mL
緩沖液 Stabilization buffer with preservatives
儲存液 Other preservative
注意事項 Avoid repeated freezing and thawing.
儲存條件 4 °C/-20 °C
儲存方法 Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

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