DOK1抗體

抗原
Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1)
別名 4432404K01Rik, ARTC4, DO, DOK1, AW557123, p62DOK, Dok-1, P62DOK
抗原表位
其他選擇 C-Term
pTyr398(40),pTyr362 (39),N-Term (15),C-Term (13),pSer450 (13),Tyr362 (6),Tyr398 (6),AA 360-364 (5),AA 1-481 (4),AA 396-400 (3),AA 24-39 (2),AA 425-439 (2),AA 9-39 (2),AA 277-481 (1),AA 329-378 (1),AA 365-414 (1),AA 9-277 (1),Arg392 (1),Pro356 (1)
適用
其他選擇 Human
Human(210),Murine (120),Rat ((Rattus)) (120),Bovine (36),Dog (Canine) (36),Pig (Porcine) (36)
宿主
其他選擇 Rabbit
Rabbit(209),Mouse (2)
克隆類型
多克隆
標記
其他選擇 非結合性
Biotin(6),FITC (6),HRP (6),Alexa Fluor 350 (4),Alexa Fluor 488 (4),Alexa Fluor 555 (4),Alexa Fluor 647 (4),Cy3 (4),Cy5 (4),Cy5.5 (4),Cy7 (4),APC (1),Alkaline Phosphatase (AP) (1),PE (1)
應用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(165),Immunohistochemistry (IHC) (73),ELISA (53),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (45),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (40),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (15),Immunofluorescence (IF) (14),Flow Cytometry (FACS) (10),Immunocytochemistry (ICC) (10),Immunoassay (IA) (4),Immunoprecipitation (IP) (2),Enzyme Immunoassay (EIA) (1),Immunohistochemistry (Acetone-fixed) (IHC (af)) (1),Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
[Pubmed] 2 references available
規(guī)格 50 μg
發(fā)貨至 中國 (更改)
發(fā)貨時間 9至12個工作日

DOK1抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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免疫原 Synthetic peptide directed towards the C terminal of human DOK1
序列 EPGTATGSGI KSHNSALYSQ VQKSGASGSW DCGLSRVGTD KTGVKSEGST
預測反應 Human : 100 %, Horse : 80 %
產(chǎn)品特性 This is a rabbit polyclonal antibody against DOK1. It was validated on Western Blot using a cell lysate as a positive control.
純化方法 Affinity Purified

目標詳細情況

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目標詳細情況

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別名 DOK1
背景 DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
分子量 53 kDa
基因ID 1796
NCBI Accession NM_001381, NP_001372
UniProt Q99704
研究領域 Cancer, Tyrosine Kinases

使用細節(jié)

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使用細節(jié)

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應用備注 Optimal working dilutions should be determined experimentally by the investigator.
說明

Antigen size: 481 AA

限制 For Research Use only

貯存及處理

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貯存及處理

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狀態(tài) Lyophilized
溶解方式 Add 50 µL of distilled water.
濃度 1 mg/mL
緩沖液 PBS buffer with 2 % sucrose
注意事項 Avoid repeated freeze-thaw cycles.
儲存條件 -20 °C
儲存方法 For longer periods of storage, store at -20 °C

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