BMPR2抗體

抗原
Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2)
別名 BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK, 2610024H22Rik, AL117858, AW546137, BB189135, BMP-2, BMPR-2, BMPRII, Gm20272, Bmpr-II, bmprii
抗原表位
其他選擇 AA 1-151
N-Term(18),AA 27-56 (6),AA 37-66 (6),AA 1-151 (3),AA 939-1037 (3),AA 28-59 (2),AA 667-951 (2),AA 1-1038 (1),AA 1-359 (1),AA 1-389 (1),AA 26-151 (1),AA 295-552 (1),AA 324-728 (1),AA 34-49 (1),AA 374-698 (1),AA 667-921 (1)
適用
其他選擇 Human
Human(72),Murine (35),Rat ((Rattus)) (30),Monkey (13),Chicken (12),Bovine (12),Pig (Porcine) (12)
宿主
其他選擇 Rabbit
Rabbit(50),Mouse (21),Goat (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(3),FITC (3),HRP (3),APC (2),Alkaline Phosphatase (AP) (2),PE (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
zui低檢測濃度 0.00245 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(51),ELISA (39),Immunohistochemistry (IHC) (32),Flow Cytometry (FACS) (28),Immunocytochemistry (ICC) (12),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunofluorescence (IF) (9),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8),Enzyme Immunoassay (EIA) (3),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (3),Immunoassay (IA) (1)
[Pubmed] 2 references available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

BMPR2抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
亞型 IgG
特異性 Human BMPR2 / BMPR-II / PPH1
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human BMPR2 (rh BMPR2, NP_001195.2, Met 1-Ile 151). Total IgG was purified by Protein A affinity chromatography .
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 BMPR2
背景 The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signaling leads to exaggerated TGF-beta signaling and altered cellular responses to TGF-beta. In endothelial cells, BMPR2 mutation increases the susceptibility of cells to apoptosis. BMPR2 transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. The intracellular domain of BMPR2 is both necessary and sufficient for receptor complex interaction. It had been identified that BMPR2 plays a key role in cell growth. Its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. The C-terminal tail of BMPR2 provides binding sites for a number of regulatory proteins that may initiate Smad-independent signalling. BMPR2 mutations were predicted to alter the BMP and TGF- b1/SMAD signalling pathways, resulting in proliferation rather than apoptosis of vascular cells, and greatly increase the risk of developing severe pulmonary arterial hypertension. BMPR2 gene result in familial Primary pulmonary hypertension (PPH) transmitted as an autosomal dominant trait, albeit with low penetrance. Heterozygous germline mutations of BMPR2 gene have been identified in patients with familial and sporadic PPH, indicating that BMPR2 may contribute to the maintenance of normal pulmonary vascular structure and function. Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR2 and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. BMPR2 and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH.
NCBI Accession NP_001195.2
研究領(lǐng)域 Cardiovascular, Hypertrophy, Extracellular Matrix

使用細(xì)節(jié)

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1.0 μg/mL This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human BMPR2. The detection limit for Human BMPR2 is 0.00245 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項(xiàng) Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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