FCN1抗體

抗原
Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1)
別名 FCN1, FCNM, FCNB, FCN2, Fcna, Fcn1
抗原表位
其他選擇 AA 1-326
AA 1-326(13),AA 238-267 (7),C-Term (7),Middle Region (3),Internal Region (2),AA 18-284 (1),AA 201-300 (1),AA 201-301 (1),AA 25-317 (1),AA 45-249 (1),AA 95-314 (1)
適用
其他選擇 Human
Human(49),Rat ((Rattus)) (5),Murine (4),Bovine (1),Pig (Porcine) (1)
宿主
其他選擇 Rabbit
Rabbit(40),Mouse (12)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
APC(1),Alkaline Phosphatase (AP) (1),Biotin (1),FITC (1),HRP (1),PE (1)
zui低檢測濃度 0.039 ng/well
應(yīng)用范圍
其他選擇 ELISA
Western Blotting (WB)(36),ELISA (28),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6),Immunoassay (IA) (4),Immunocytochemistry (ICC) (2),Immunohistochemistry (Frozen Sections) (IHC (fro)) (2),Immunoprecipitation (IP) (2),Immunohistochemistry (IHC) (1)
[Pubmed] 1 reference available
規(guī)格 100 μg
發(fā)貨至 中國 (更改)

FCN1抗體

產(chǎn)品細(xì)節(jié)

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產(chǎn)品細(xì)節(jié)

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亞型 IgG
特異性 Human Ficolin-1 / Ficolin-A
產(chǎn)品特性 Produced in rabbits immunized with purified, recombinant Human FCN1 (rh FCN1, NP_001994.2, Met 1-Ala 326). Total IgG was purified by Protein A affinity chromatography.
純化方法 Affinity Purified
過濾 0.2 μm filtered

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 FCN1
背景 Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.
NCBI Accession NP_001994.2
研究領(lǐng)域 Immunology

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA ELISA: 0.5-1 μg/mL This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human FCN1. The detection limit for Human FCN1 is 0.039 ng/well.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS with 5% trehalose
儲存液 Without preservative
注意事項 Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
儲存條件 4 °C/-20 °C/-80 °C
儲存方法 This antibody can be stored at 2 °C-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C.
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