TOM1L1抗體

抗原
Target of Myb1 (Chicken)-Like 1 (TOM1L1)
別名 MGC52738, srcasm, TOM1L1, OK/KNS-CL.3, SRCASM, RGD1562626, Srcasm, 2310045L10Rik, C80573
適用
其他選擇 Human
Human(45),Murine (2)
宿主
其他選擇 Rabbit
Rabbit(35),Goat (6),Mouse (5)
克隆類型
多克隆
標記
其他選擇 Cy5.5
Biotin(2),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy7 (1),PE (1)
應用范圍
其他選擇 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Western Blotting (WB)(38),ELISA (18),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (9),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9),Immunohistochemistry (IHC) (7),Enzyme Immunoassay (EIA) (2),Immunoassay (IA) (2),Immunocytochemistry (ICC) (2),Immunofluorescence (IF) (2),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1)
規(guī)格 100 μL
發(fā)貨至 中國 (更改)

TOM1L1抗體

產品細節(jié)

貯存及處理 使用細節(jié) 目標詳細情況 回頁首

產品細節(jié)

顯示 隱藏
免疫原 KLH conjugated synthetic peptide derived from human TOM1L1
亞型 IgG
純化方法 purified by Protein A

目標詳細情況

貯存及處理 使用細節(jié) 回頁首

目標詳細情況

顯示 隱藏
別名 TOM1L1
背景 Tom1L-1 is a 476 amino acid Golgi apparatus protein belonging to the TOM1 family and is a member of the multivesicular body (MVB) sorting machinery. Containing a GAT domain and a VHS domain, Tom1L-1 interacts with Fyn, GRB2, PI 3-kinase p85?and various signaling proteins when phosphorylated. GAT domain of Tom1L1 binds ubiquitin, suggesting participation in the sorting of ubiquitinated proteins into MVBs. Tom1L-1 may act as an adapter protein involved in signaling pathways and may promote Fyn activation, possibly by disrupting intramolecular SH3-dependent interactions. As an interactor and a substrate of Src tyrosine kinases (SFK), Tom1L1 is considered a novel mechanism involved in negative regulation of SFK mitogenic and transforming signals. Tom1L1 modulates SFK partitioning at the plasma membrane and downregulates Src kinases in an endosomal-dependent manner. It is suggested that Tom1L-1 functions as an anti-oncogene by inhibiting the formation of squamous cell carcinomas in skin.
研究領域 Signaling, Tyrosine Kinases

使用細節(jié)

貯存及處理 目標詳細情況 回頁首

使用細節(jié)

顯示 隱藏
應用備注 IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.
說明

Excitation / Emission wavelength: 675nm / 694nm

限制 For Research Use only

貯存及處理

使用細節(jié) 目標詳細情況 回頁首

貯存及處理

顯示 隱藏
狀態(tài) Liquid
濃度 1 μg/μL
緩沖液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
儲存液 Sodium azide
注意事項 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲存條件 4 °C

xy-1360R GADD45生長抑制DNA損傷基因45抗體
xy-0098R GIP胃泌素抑制肽抗體
xy-0384R GLUT4葡萄糖轉運蛋白4抗體
xy-1112R glypican 3磷脂酰基醇蛋白聚糖-3抗體
xy-0252R Glucocorticoid receptor(GR) 糖皮質激素受體抗體
xy-0038R GLP-1 (7-36)胰高血糖素樣肽-1抗體
xy-1207R GLUT3葡萄糖轉運蛋白3抗體
xy-1160R Gelsolin凝溶膠蛋白抗體
xy-0205R GHRH生長激素釋放激素抗體
xy-0199R GFAP膠質纖維酸性蛋白抗體
xy-0639R GFP綠色熒光蛋白（免疫組化用抗體）
xy-0654R GHR生長激素受體抗體
xy-0467R Ghrelin腦腸肽抗體
xy-1226R GPA33糖蛋白A33抗體
xy-1375R Ghrelin 28腦腸肽抗體
xy-0208R GLP-2胰高血糖素樣肽-2抗體
xy-15376R GPR114G蛋白偶聯(lián)受體GPR114蛋白抗體
xy-9845R GDN膠質源性連接蛋白抗體
xy-9897R Glycoprotein VI糖蛋白VI/六糖蛋白抗體
xy-13462R GMPR1鳥苷酸還原酶1抗體
xy-7611R G2 and S phase expressed 1G2期/S期應答相關蛋白1抗體
xy-6879R phospho-GATA4 (Ser262)磷酸化GATA結合蛋白4抗體
xy-1787R GATA6GATA結合蛋白6抗體
xym-0933M GLP-1(1G9)GLP-1單克隆抗體
xy-1351R Granzyme B顆粒酶B抗體
xy-1380R GPR30G蛋白偶聯(lián)受體30抗體
xy-9326R GDAP2神經節(jié)苷脂誘導分化相關蛋白2抗體