GSK3a抗體 

抗原
Glycogen Synthase Kinase 3 alpha (GSK3a)
別名 GSK3A, CG5182, DmelCG5182, GSK3a, 2700086H06Rik, xgsk3, GSK-3[a], GSK-3[b], GSK3, gsk3a
抗原表位
其他選擇 pSer21
pSer21(55),C-Term (26),N-Term (20),AA 347-376 (7),AA 16-25 (6),Ser21 (5),AA 19-23 (3),AA 448-478 (3),pSer9 (3),pTyr216 (3),pTyr279 (3),AA 348-376 (2),pTyr215 (2),pTyr278 (2),phosphospecific (2),AA 10-59 (1),AA 115-409 (1),AA 122-406 (1),AA 198-483 (1),AA 203-219 (1),AA 248-467 (1),AA 471-483 (1),AA 89-100 (1),Glu120 (1),Gly15 (1),Gly273 (1),Ser45 (1),Ser9 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus)), Chicken, Dog (Canine), Pig (Porcine)
Human(218),Murine (112),Rat ((Rattus)) (102),Chicken (26),Dog (Canine) (25),Pig (Porcine) (23),Zebrafish (6),Monkey (4),Bovine (2),Fruit Fly (Drosophila melanogaster) (2)
宿主
其他選擇 Rabbit
Rabbit(164),Mouse (69),Chicken (3)
克隆類型
多克隆
標(biāo)記
其他選擇 Alexa Fluor 488
HRP(13),Biotin (6),FITC (6),APC (3),Alkaline Phosphatase (AP) (3),PE (3),Sepharose (3),Alexa Fluor 350 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),Alexa Fluor 488 (1)
應(yīng)用范圍
其他選擇 Immunofluorescence (Paraffin-embedded Sections) (IF (p))
Western Blotting (WB)(200),Immunohistochemistry (IHC) (86),ELISA (81),Immunoprecipitation (IP) (43),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (39),Immunofluorescence (IF) (33),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (19),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (14),Immunocytochemistry (ICC) (10),Enzyme Immunoassay (EIA) (7),Immunohistochemistry (Frozen Sections) (IHC (fro)) (6),Flow Cytometry (FACS) (1)
規(guī)格 100 μL
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GSK3a抗體 

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha around the phosphorylation site of pSer21
亞型 IgG
特異性 Excitation / Emission Wavelengths: 499nm/519nm
交叉反應(yīng) Rat ((Rattus)), Chicken, Dog (Canine), Pig (Porcine)
純化方法 purified by Protein A

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目標(biāo)詳細(xì)情況

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別名 GSK3 Alpha
背景 Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acuy leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
分子量 54kDa
基因ID 2931

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應(yīng)用備注 IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.
說(shuō)明

Excitation / Emission wavelength: 495nm / 519nm

限制 For Research Use only

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狀態(tài) Liquid
濃度 1 μg/μL
緩沖液 Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲(chǔ)存條件 4 °C

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