MCL1抗體

抗原
Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1)
別名 AW556805, Mcl-1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, TM, bcl2-L-3, mcl1/EAT, mcl-1
抗原表位
其他選擇 C-Term
Internal Region(19),pSer159 (19),C-Term (16),AA 121-139 (12),pThr163 (12),N-Term (9),AA 216-245 (7),Middle Region (4),AA 1-327 (3),AA 148-152 (3),BH3 Domain (3),AA 191-226 (2),Center (2),AA 106-155 (1),AA 119-347 (1),AA 125-174 (1),AA 125-175 (1),AA 147-219 (1),AA 151-250 (1),AA 2-307 (1),AA 6-328 (1),AA 75-125 (1),AA 91-140 (1),Isoform 1 (1),Ser121 (1),Ser155 (1),Ser87 (1)
適用
其他選擇 Human, Murine, Rat ((Rattus))
Human(229),Murine (81),Rat ((Rattus)) (58),Dog (Canine) (18),Bovine (12),Cat (3),Monkey (3),Pig (Porcine) (2),Rabbit (2),Rat (Meriones) (1)
宿主
其他選擇 Rabbit
Rabbit(162),Mouse (64),Goat (5),Sheep (1)
克隆類(lèi)型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(7),FITC (4),HRP (4),APC (2),Alexa Fluor 350 (2),Alexa Fluor 488 (2),Alexa Fluor 555 (2),Alexa Fluor 647 (2),Alkaline Phosphatase (AP) (2),Cy3 (2),Cy5 (2),Cy5.5 (2),Cy7 (2),PE (2)
應(yīng)用范圍
其他選擇 Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
Western Blotting (WB)(192),ELISA (84),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (74),Immunohistochemistry (IHC) (66),Immunofluorescence (IF) (52),Immunocytochemistry (ICC) (43),Immunoprecipitation (IP) (22),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (20),Flow Cytometry (FACS) (19),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (11),Immunohistochemistry (Frozen Sections) (IHC (fro)) (11),Enzyme Immunoassay (EIA) (5),Immunoassay (IA) (1),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (1)
[Pubmed] 1 reference available
規(guī)格 0.1 mg
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發(fā)貨時(shí)間 29至35個(gè)工作日

MCL1抗體

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產(chǎn)品細(xì)節(jié)

顯示 隱藏
免疫原 Mcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human Mcl-1.
亞型 IgG
特異性 This antibody detects MCL1 at C-term.
交叉反應(yīng) （詳細(xì)） Species reactivity (tested):Human, mouse, rat
純化方法 Ion exchange chromatography

目標(biāo)詳細(xì)情況

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目標(biāo)詳細(xì)情況

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別名 MCL1
背景 Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak (2,3). Mcl-1 was originally identified in differentiating myeloid cells (4), but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals (3). Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death (6).Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004
基因ID 4170
NCBI Accession NP_068779
UniProt Q07820
研究領(lǐng)域 Cancer, Apoptosis/Necrosis

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使用細(xì)節(jié)

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應(yīng)用備注 ELISA: Western blot: 1 to 2?μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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緩沖液 PBS containing 0.02?% sodium azide
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事項(xiàng) Avoid repeated freezing and thawing.
儲(chǔ)存條件 4 °C/-20 °C
儲(chǔ)存方法 Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

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