14-3-3 α + β蛋白抗體

英文名稱 14-3-3 alpha + beta
中文名稱 14-3-3 α + β蛋白抗體
別    名 14 3 3 alpha; 14 3 3 protein beta/alpha; 14-3-3 protein beta/alpha; 1433B_HUMAN; Brain protein 14 3 3 beta isoform; GW128; HS 1; KCIP-1; KCIP1; N-terminally processed; Protein 1054; Protein kinase C inhibitor protein 1; YWHAA; YWHAB.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human 14-3-3 alpha/beta
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
14-3-3 are activates tyrosine and tryptophan hydroxylases in the presence of Ca (2+)/calmodulin-dependent protein kinase II, and strongly activates protein kinase C. Is probably a multifunctional regulator of the cell signaling processes mediated by both kinases. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. They may be also present, at lower levels, in various other eukaryotic tissues. It belongs to the 14-3-3 family.

Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.

Subcellular Location:
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Post-translational modifications:
The alpha, brain-specific form differs from the beta form in being phosphorylated.
Isoform Short contains a N-acetylmethionine at position 1.

Similarity:
Belongs to the 14-3-3 family.xy-12437R    Inversin內(nèi)臟器官發(fā)育轉(zhuǎn)位相關(guān)蛋白NPH2抗體
xy-4995R    Insulin receptor subunit beta胰島素受體β抗體
xy-5129R    ITLN1內(nèi)皮細(xì)胞凝集素HL1抗體
xy-8995R    IFN-Alpha干擾素α抗體
xy-7333R    IL-17F白介素-17F抗體
xy-4540R    IL-6 (NT)白介素6抗體(N端)
xy-4587R    IL-6白介素6抗體
xy-15556R    IFNE1干擾素epsilon 1蛋白抗體
xy-5393R    phospho-IKK gamma(Ser43)磷酸化KB抑制蛋白激酶γ抗體
xy-5394R    phospho-IL-1R1(Tyr496)磷酸化白介素1受體1抗體
xy-4510R    IL-3白介素3抗體
xy-5073R    IDI1異戊烯焦磷酸1抗體
xy-3202R    phospho-IRS1(Ser789)磷酸化胰島素受體底物-1抗體
xy-3201R    phospho-IRS1(Ser636 + Ser639)磷酸化胰島素受體底物-1抗體
xy-5074R    Insig1胰島素誘導(dǎo)基因1抗體
xy-6028R    CD16FC段γ受體3/免疫球蛋白G Fc段受體III抗體
xy-4080R    phospho-IRAK4 (Thr345)磷酸化白介素-1受體相關(guān)激酶4抗體
xy-9024R    IQCF1IQCF1蛋白抗體
xy-9021R    IQCJIQCJ蛋白抗體
xy-9194R    IGSF1抑制素結(jié)合蛋白抗體
xy-9196R    IGSF3免疫球蛋白超家族成員3抗體
xy-9198R    IGSF6免疫球蛋白超家族成員6抗體
xy-9199R    IGSF9免疫球蛋白超家族成員9抗體
xy-9200R    IGSF10免疫球蛋白超家族成員10抗體
xy-9201R    IGSF11大腦和睪丸特異性免疫球蛋白超家族成員11抗體
xy-4116R    IFNAR1干擾素α受體抗體
xy-5457R    phospho-IFNAR1(Ser535+Ser539)磷酸化干擾素α受體抗體
xy-5453R    Phospho-Insulin Receptor Beta (Tyr1185)磷酸化胰島素受體β抗體
xy-4114R    IKBKE核因子κB抑制蛋白E抗體
xy-5455R    phospho-ITGB4(Tyr1494)磷酸化整合素β4抗體
xy-5456R    phospho-ITGB4(Tyr1526)磷酸化整合素β4抗體
xy-9017R    IQCDIQCD蛋白抗體
xy-9019R    IQCCIQCC蛋白抗體
xy-9020R    IQCA1IQCA1蛋白抗體
xy-9766R    INTS3集成復(fù)雜蛋白亞單位3抗體
xy-15519R    IFNA14干擾素alpha 14蛋白抗體