紡錘體組裝異常蛋白6抗體

英文名稱 SASS6
中文名稱 紡錘體組裝異常蛋白6抗體
別    名 HsSAS 6; HsSAS6; MGC119440; SAS 6; SAS6; SASS 6; Spindle assembly 6 homolog (C.
說 明 書 0.2ml  
研究領(lǐng)域 細胞生物  免疫學(xué)  細胞周期蛋白  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
細胞定位 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SASS6
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. xy-13661R    SLP76淋巴細胞胞漿蛋白2抗體
xy-13662R    phospho-SLP76 (Tyr145)磷酸化淋巴細胞胞漿蛋白2抗體
xy-13663R    phospho-SLP76 (Tyr113)磷酸化淋巴細胞胞漿蛋白2抗體
xy-13665R    SOCS7信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子7抗體
xy-13667R    STAP2信號轉(zhuǎn)導(dǎo)接頭蛋白2抗體
xy-13668R    SLAPSLAP蛋白抗體
xy-2014R    SCP2固醇攜帶蛋白2抗體
xy-13664R    SOCS5信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5抗體
xy-10415R    SLC4A4碳酸氫鈉協(xié)同轉(zhuǎn)運蛋白4-A4抗體
xy-11950R    SHISA9SHISA蛋白家族9抗體
xy-0726R    Survivin細胞凋亡抑制因子抗體
xy-4101R    Separase外紡錘體極樣蛋白1抗體
xy-1659R    phospho-STAT5a(Tyr694)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5a抗體
xy-0130R    SARS S-protein抗冠狀病毒表面S蛋白抗體
xy-0121R    SYAP1突觸素抗體/突觸相關(guān)蛋白-1
xy-0088R    Secretin分泌素抗體
xy-0444R    Slc22A17可溶性載質(zhì)轉(zhuǎn)運蛋白22A17抗體
xy-1730R    phospho-Src(Tyr529)磷酸化Src原癌基因抗體
xy-3567R    SHIP1SH2結(jié)構(gòu)含磷酸肌醇SHIP1抗體
xy-1684R    SKIC-SKI抗體
xy-3397R    Phospho-SGK1 (Thr256)磷酸化糖皮質(zhì)激素調(diào)節(jié)激酶1抗體
xy-3390R    Phospho-SATB1 (Ser47)磷酸化核基質(zhì)結(jié)合區(qū)結(jié)合蛋白1抗體
xy-3395R    Phospho-SGK1 (Ser78)磷酸化糖皮質(zhì)激素調(diào)節(jié)激酶1抗體
xy-3396R    Phospho-SGK1 (Ser422)磷酸化糖皮質(zhì)激素調(diào)節(jié)激酶1抗體
xy-1303R    SFRP1分泌型卷曲相關(guān)蛋白1抗體
xy-4905R    SORBS2精氨酸結(jié)合蛋白2抗體
xy-8717R    SLC30A3溶質(zhì)載體鋅轉(zhuǎn)運3抗體
xy-8324R    SERPINB13絲氨酸蛋白酶抑制劑13抗體
xy-8330R    STK25絲氨酸/蘇氨酸激酶25抗體