減數(shù)分裂重組蛋白SPO11抗體

英文名稱 SPO11
中文名稱 減數(shù)分裂重組蛋白SPO11抗體
別    名 Meiotic recombination protein SPO 11; Meiotic recombination protein SPO11; MGC39953; SPO 11; SPO11 meiotic protein covalently bound to DSB homolog; SPO11 meiotic protein covalently bound to DSB like; SPO11_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  細(xì)胞周期蛋白  細(xì)胞分化  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPO11
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Spo11 is a type II topoisomerase that is thought to generate the chromosome breaks that initiate meiotic recombination. The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic synapsis in S. cerevisiae. The DSBs are located mostly in promoter regions, where the chromatin is in an open configuration, and cluster in domains along the chromosome. Expression of the Spo11 is detected mainly in the testis, in agreement with its predicted function in the initiation of meiotic recombination. Disruption of Spo11 leads to severe gonadal abnormalities from defective meiosis and results in infertility.

Function:
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity). 

Subcellular Location:
Nuclearxy-7879R    SUPT16H染色體特異性轉(zhuǎn)錄延伸因子抗體
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xy-7732R    Separase外紡錘體極樣蛋白1抗體
xy-3667R    SLC44A1溶質(zhì)轉(zhuǎn)運(yùn)蛋白家族44成員1抗體
xy-10085R    SLC7A9離子轉(zhuǎn)運(yùn)相關(guān)蛋白SLC7A9抗體
xy-8610R    SLC20A2溶質(zhì)載體蛋白家族20成員2抗體
xy-10098R    S100A6S100鈣結(jié)合蛋白A6抗體
xy-12364R    SCXA堿性螺旋-環(huán)-螺旋轉(zhuǎn)錄因子SCXA抗體
xy-12346R    Stabilin 2清道夫受體STAB2抗體
xy-12351R    STRA6維甲酸誘導(dǎo)蛋白6抗體
xy-10200R    Sclerostin骨形態(tài)發(fā)生抑制蛋白SOST抗體
xy-10367R    Sarcomeric Alpha Actininα橫紋肌輔肌動(dòng)蛋白/α-SCA抗體
xy-12317R    SCUBE3新型分泌細(xì)胞表面蛋白/成骨細(xì)胞相關(guān)蛋白SCUBE3抗體
xy-12318R    SCUBE2內(nèi)皮分泌蛋白SCUBE2抗體
xy-7120R    Sulfite oxidase亞硫酸鹽氧化酶抗體
xy-8877R    Somatostatin生長抑素抗體
xy-10315R    phospho-Syntaxin 1a(Ser188)磷酸化突觸融合蛋白1抗體
xy-3787R    SCD1固醇酰輔酶A脫氫酶1抗體
xy-6015R    SNF2L解旋酶SNF2L抗體
xy-3829R    Sorbitol Dehydrogenase山梨醇脫氫酶抗體
xy-2381R    Signal recognition particle信號識別顆粒抗體
xy-6158R    SH2D3ASH2結(jié)構(gòu)域蛋白3A抗體
xy-2943R    SEMA6D軸突導(dǎo)向因子SEMA6D抗體
xy-6531R    SKALP彈性蛋白酶抑制劑抗體
xy-2971R    STK39絲氨酸/蘇氨酸蛋白激酶39抗體
xy-5621R    phospho-STAT5a(Tyr694)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5a抗體
xy-5633R    phospho-SYT1(Thr202)磷酸化突觸結(jié)合蛋白1抗體
xy-5619R    phospho-STAT5a(Ser726)磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5a抗體