絲氨酸/精氨酸相關(guān)核基質(zhì)蛋白2抗體

英文名稱 SRRM2
中文名稱 絲氨酸/精氨酸相關(guān)核基質(zhì)蛋白2抗體
別    名 300 kDa nuclear matrix antigen; CWC21; KIAA0324; Ser/Arg-related nuclear matrix protein of 300 kDa; Serine/arginine repetitive matrix protein 2; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; Splicing coactivator subunit SRm300; SR-related nuclear matrix protein of 300 kDa; SRL300; SRM300; SRRM2; SRRM2_HUMAN; Tax-responsive enhancer element-binding protein 803; TaxREB803.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 299kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SRRM2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The SRm160/300 splicing coactivator, which consists of the serine/arginine (SR)-related nuclear matrix protein and a nuclear matrix antigen, functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA. This splicing pathway involves five core small nuclear ribonucleoprotein particles (snRNPs) and the SR family proteins, which coordinay bind to pre-mRNA slicing enhancer elements, are required for accurate splice site recognition, and regulate alterative splicing patterns. The recognized splicing enhancer elements, known also as exonic enhancer splicing sequences, are short RNA sequences that are capable of activating weak splice sites in adjacent introns and contain specific binding sites for the serine/arginine (SR)-rich splicing factors. SRm160 and 300 antigens contain domains rich in SR motifs, but are distinctly different from the SR factors as they lack an RNA recognition motif and cannot directly induce RNA splicing. These proteins rather function as coactivators that stabilize the splicing complex and mediate the U1 snRNP-splicing pathway.

Function:
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate By similarity. Binds to RNA. xy-6300R    TEM7R腫瘤血管內(nèi)皮標(biāo)記相關(guān)蛋白質(zhì)7抗體
xy-6220R    TRIM31環(huán)指蛋白HCG1抗體
xy-11489R    TNRC6B三核苷酸重復(fù)蛋白6B抗體
xy-11490R    Torsin A扭轉(zhuǎn)蛋白A抗體
xy-10106R    phospho-Tau protein (Thr548)磷酸化微管相關(guān)蛋白抗體
xy-10107R    phospho-Tau protein(Ser739)磷酸化微管相關(guān)蛋白抗體
xy-10108R    phospho-Tau protein (Ser579)磷酸化微管相關(guān)蛋白抗體
xy-10109R    phospho-Tau protein(Ser531)磷酸化微管相關(guān)蛋白抗體
xy-10110R    phospho-Tau protein(Ser516)磷酸化微管相關(guān)蛋白抗體
xy-10111R    phospho-Tau protein(Ser552)磷酸化微管相關(guān)蛋白抗體
xy-10112R    phospho-Tau protein(Thr529)磷酸化微管相關(guān)蛋白抗體
xy-10113R    phospho-Tau protein(Thr522)磷酸化微管相關(guān)蛋白抗體
xy-10114R    phospho-Tau protein(Ser673)磷酸化微管相關(guān)蛋白抗體
xy-10115R    phospho-Tau protein(Ser733)磷酸化微管相關(guān)蛋白抗體
xy-10116R    phospho-Tau protein(Ser519)磷酸化微管相關(guān)蛋白抗體
xy-11437R    TRAP80MED17抗體
xy-11438R    TRIP13甲狀腺激素受體相互作用13/乳頭瘤病毒16型E1結(jié)合蛋白抗體
xy-11440R    THRB1甲狀腺激素受體β抗體(THβ1，THβ2)
xy-7508R    THSD1血小板跨膜反應(yīng)蛋白1抗體
xy-4690R    CD142組織因子抗體
xy-5725R    TNFSF13腫瘤壞死因子配體超家族成員13抗體
xy-6607R    TSPY1睪丸特異定蛋白質(zhì)編碼Y1抗體
xy-6241R    TM4SF3跨膜蛋白4超家族成員3抗體
xy-6601R    TLR7Toll樣受體7抗體
xy-6240R    TLX3T細(xì)胞白血病同源盒蛋白3抗體
xy-5707R    TUSC2血小板源性生長因子A相關(guān)蛋白2抗體
xy-11694R    TMEM106B跨膜蛋白106B抗體
xy-11688R    Tau421微管相關(guān)蛋白Tau421抗體
xy-11980R    CABP4瞬時(shí)受體電位通道蛋白4抗體
xy-7955R    TPTE腫瘤/睪丸抗原44抗體
xy-7939R    TACC1乳腺癌、胃癌抗原GA55抗體
xy-7924R    TBRG4轉(zhuǎn)化生長因子β調(diào)節(jié)蛋白4抗體