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當(dāng)前位置:上海信裕生物科技有限公司>>抗體>>一抗>> 細(xì)胞衰老相關(guān)蛋白1抗體
產(chǎn)品型號
品 牌Abcam
廠商性質(zhì)生產(chǎn)商
所 在 地上海
更新時(shí)間:2015-06-01 13:22:37瀏覽次數(shù):455次
聯(lián)系我時(shí),請告知來自 化工儀器網(wǎng)細(xì)胞衰老相關(guān)蛋白1抗體
英文名稱 SEN1
中文名稱 細(xì)胞衰老相關(guān)蛋白1抗體
別 名 Cell senescence related gene complementation group B; Cellular senescence related protein 1; CSR; CSRB; MORF 4; MORF4; MORF4 protein; Mortality factor 4; SEN 1; SEN; Senescence (cellular) related 1; Senescence related cellular 1; Transcription factor like protein MORF4; MO4L1_HUMAN; Mortality factor 4-like protein 1; MORF-related gene 15 protein; Protein MSL3-1; Transcription factor-like protein MRG15.
說 明 書 0.2ml
研究領(lǐng)域 細(xì)胞生物 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 表觀遺傳學(xué)
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, Zebrafish,
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
細(xì)胞定位 細(xì)胞核
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Mortality factor 4-like protein 1
亞 型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產(chǎn)品介紹 background:
Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to one of several complementation groups. SEN1 or MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B. It is capable of reversing the immortal phenotype of a subset of immortal cells. Overexpression of SEN1 in HeLa cells ultimay caused abnormal nuclear morphology and cell death.
Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.xy-8055R KLHL11Kelch樣蛋白11抗體
xy-8053R KLHL3Kelch樣蛋白3抗體
xy-8056R KLHL14Kelch樣蛋白14抗體
xy-8057R KLHL31Kelch樣蛋白31抗體
xy-8058R KLHL32Kelch樣蛋白32抗體
xy-1837R KCNA5鉀電壓閥門通道混合器相關(guān)亞家族成員5抗體
xy-1838R KLF10TGF-β誘導(dǎo)早期應(yīng)答基因1抗體
xy-1575R KCNA3離子通道蛋白Kv1.3抗體
xy-2019R phospho-KLF5(Ser272)磷酸化KLF5抗體
xy-2020R phospho-KLF5(Ser275)磷酸化KLF5抗體
xy-1815R ERG/KCNH2特異性鉀離子通道蛋白抗體
xy-7107R KIF4A沉默驅(qū)動(dòng)蛋白KIF4A抗體
xy-6468R kir 6.1ATP敏感鉀離子通道蛋白抗體
xy-13762R KIAA1462KIAA1462蛋白抗體
xy-13763R KIAA1549KIAA1549蛋白抗體
xy-4643R KRV-VP1+KRV-VP2 (C-terminus)基爾曼氏細(xì)小病毒VP1/VP2抗體(大鼠潛在病毒KRV)C端
xy-7515R KLHL20Kelch樣蛋白20抗體
xy-5786R KLST激肽釋放酶抑制劑抗體
xy-5935R KLHL7kelch樣蛋白7抗體
xy-5933R KCNK 9TWIK相關(guān)酸敏感鉀離子通道蛋白9抗體
xy-5870R KLK6激肽釋放酶6抗體
xy-5871R KLK8激肽釋放酶8抗體
xy-5872R KLKB1血漿激肽釋放酶抗體
xy-6529R phospho-EZH2 (Thr487)磷酸化抑癌蛋白EZH2抗體
xy-6139R KDM5B組蛋白去甲基化酶JARID1B抗體
xy-4144R Keratan Sulfate硫酸角質(zhì)素抗體
xy-7719R KRG2角質(zhì)細(xì)胞生長因子調(diào)節(jié)蛋白2抗體
xy-2886R KCNG4鉀離子通道蛋白G蛋白4抗體
xy-12178R KCTD18鉀通道多聚體結(jié)構(gòu)域KCTD18抗體
xy-4900R KEAP1胞質(zhì)接頭蛋白Keap1
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