電壓門控鈉通道SCN3B蛋白抗體

英文名稱 SCN3B
中文名稱 電壓門控鈉通道SCN3B蛋白抗體
別    名 SCNB3; Sodium channel, beta 3 subunit; sodium channel, voltage-gated, type III, beta; SCN3B_HUMAN.

說 明 書 0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCN3B
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
SCN3B is one member of the sodium channel beta subunits of voltage-gated sodium channels, which are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B influences the inactivation kinetics of the sodium channel.

Function:
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).

Subunit:
The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2 and/or beta-3 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Beta-1 or beta-3 subunits associate with neurofascin. Associates with SCN10A (By similarity).

DISEASE:
Brugada syndrome 7 (BRGDA7) [MIM:613120]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. Note=The disease is caused by mutations affecting the gene represented in this entry.xy-2044R    LOX 1凝集素樣氧化型低密度脂蛋白受體抗體
xy-2661R    MD1MD-1蛋白抗體
xy-2662R    MD-2MD-2蛋白抗體
xy-1311R    LYVE-1淋巴管內(nèi)皮透明質(zhì)酸受體抗體
xy-0897R    liver FABP肝臟型脂肪酸結(jié)合蛋白抗體
xy-8539R    Luciferase熒光素酶抗體
xy-7687R    LAP3亮氨酸氨基肽酶3抗體
xy-0824R    LFABP/FABP-1肝臟型脂肪酸結(jié)合蛋白抗體
xy-8527R    LPP2腫瘤抑制基因LPP2抗體
xy-2904R    LATS1腫瘤抑制基因LATS1抗體
xy-3247R    Phospho-LIMK1(Thr508) + LIMK2(Thr505)磷酸化單絲氨酸蛋白激酶1/2抗體
xy-3246R    Phospho-LATS1 (Ser909)磷酸化腫瘤抑制基因LATS1抗體
xy-3248R    phospho-LKB1(Ser334)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3249R    phospho-LKB1(Ser428)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-3250R    Phospho-LKB1(Thr189)磷酸化絲氨酸/蘇氨酸蛋白激酶抗體
xy-0456R    GNRH黃體激素釋放激素類似物抗體
xy-3254R    Phospho-Lamin A + C(Ser22)磷酸化核纖層蛋白A/C抗體
xy-3255R    Phospho-Lck (Tyr505)磷酸化淋巴細(xì)胞特異性蛋白酪氨酸激酶抗體
xy-2906R    Lyn膜相關(guān)蛋白酪氨酸激酶Lyn抗體
xy-3256R    Phospho-Lyn (Tyr507)磷酸化膜相關(guān)蛋白酪氨酸激酶Lyn抗體
xy-3257R    Phospho-Lyn (Tyr397)磷酸化膜相關(guān)蛋白酪氨酸激酶Lyn抗體
xy-1974R    LRRC4腦瘤相關(guān)基因抗體
xy-11091R    LSAMP大腦邊緣系統(tǒng)相關(guān)膜蛋白抗體
xy-11087R    LRFN2神經(jīng)突觸粘附樣分子1抗體
xy-11089R    LRFN4富含亮氨酸重復(fù)序列/Ⅲ型纖維連接蛋白4抗體
xy-11056R    Laminin alpha 4層粘蛋白α4抗體(Lamininα4)
xy-11055R    Laminin alpha 4層粘蛋白α4抗體(Lamininα4)
xy-11286R    lipocalin 1脂質(zhì)運(yùn)載蛋白1抗體
xy-11287R    Lymphotactin淋巴細(xì)胞趨化因子抗體
xy-11590R    LRP5L低密度脂蛋白受體5樣蛋白抗體
xy-11571R    LRRTM3富含亮氨酸重復(fù)跨膜神經(jīng)元蛋白3抗體
xy-6439R    Lens culinaris agglutinin扁豆凝集素