內(nèi)臟脂肪組織源性絲氨酸蛋白酶抑制蛋白抗體

英文名稱 SERPINA12
中文名稱 內(nèi)臟脂肪組織源性絲氨酸蛋白酶抑制蛋白抗體
別    名 OL 64; OL-64; OL64; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 12 ; Serpin A12; Serpin A12 precursor; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 12; Serpina12; SPA12_HUMAN antibody Vaspin; Visceral adipose specific serpin; Visceral adipose tissue derived serine protease inhibitor; Visceral adipose tissue-derived serine protease inhibitor; Visceral adipose-specific serpin.
 
說 明 書 0.2ml  
研究領(lǐng)域 心血管  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
細(xì)胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SERPINA12/Vaspin
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues.
Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in their catalytic site. Some serpins inhibit other classes of protease. A number of such serpins have been shown to target cysteine proteases. These enzymes differ from serine proteases in that they are defined by the presence of a nucleophilic cysteine residue, rather than a serine residue, in their catalytic site.
SerpinA12, also known as OL-64, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin and SERPINA12, is a secreted protein which belongs to the serpin family. SerpinA12 / Vaspin is expressed in visceral adipose tissues. It may modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. SerpinA12 / Vaspin may be the compensatory molecule in the pathogenesis of metabolic syndrome and SerpinA12 / Vaspin recombinant protein or vaspin-mimicking agents such as vaspin analogs, antibodies or small molecule agents may be the link to drug discovery and development.xy-9408R    PRR15富含脯氨酸蛋白15抗體
xy-10486R    protein C light chain維生素K依賴的蛋白C輕鏈抗體
xy-10487R    protein C Activation peptide
xy-0686R    PTEN一種腫瘤抑制基因抗體（C端）
xy-1478R    PAFR血小板活化因子受體抗體
xy-5422R    PP1C gamma蛋白磷酸酶γ1抗體
xy-4181R    p53R2核苷酸還原酶M2B抗體
xy-2384R    PDE4A磷酸二酯酶4A抗體
xy-3643R    PLASTIN3絲束蛋白T Plastin抗體
xy-3638R    Plexin A2神經(jīng)叢蛋白A2抗體
xy-3640R    Plectin網(wǎng)蛋白抗體
xy-10171R    PTOV1前列腺腫瘤高表達(dá)蛋白1抗體
xy-5596R    phospho-P53(Thr55)磷酸化腫瘤抑制基因P53抗體
xy-4180R    P2Y2嘌呤ATP受體抗體
xy-2210R    phospho-p38 MAPK (Thr180 + Tyr182)磷酸化絲裂原活化蛋白激酶p38抗體
xy-2219R    Pectinesterase inhibitor 18果膠酶抑制蛋白18抗體
xy-3614R    PPAR alphaα型-過氧化酶活化增生受體抗體（PPAR α, PPAR-α）
xy-2561R    PSGD/HOXB13同源盒蛋白HOXB13抗體
xy-5537R    Phospho-PDPK1(Ser393)磷酸化3磷酸肌醇依賴性蛋白激酶1抗體
xy-3716R    Phospho-p63 (Ser160+Ser162)磷酸化P63腫瘤抑制基因抗體
xy-2270R    Phospho-PAK4(Ser99)磷酸化p21激活激酶4抗體
xy-3717R    Phospho-p73(Tyr99)磷酸化P73腫瘤抑制基因抗體
xy-3718R    Phospho-p95 NBS1 (Ser343)磷酸化DNA修復(fù)蛋白NBS1抗體
xy-1573R    PUMAp53正向細(xì)胞凋亡調(diào)控因子抗體
xy-4151R    PLDL1磷脂酶C1樣蛋白抗體
xy-6742R    Prostate and colon associated protein前列腺癌和結(jié)腸癌相關(guān)蛋白
xy-0361R    Protein G重組蛋白G抗體
xy-2067R    PIK3CA磷脂酰肌醇激酶催化亞單位A抗體
xy-1476R    PDI蛋白質(zhì)二硫鍵異構(gòu)酶抗體
xy-1345R    PODXL足細(xì)胞特異蛋白抗體
xy-2090R    P53(wt-p53)腫瘤抑制基因抗體（野生型P53）
xy-2413R    PAX7配對(duì)盒基因7抗體
xy-0655R    PAK5激活激酶PAK7抗體
xy-0420R    PIBF孕激素誘導(dǎo)阻斷因子抗體
xy-0754R    PCNA增殖細(xì)胞核抗原抗體