磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子Smad-1/5抗體

英文名稱 Phospho-Smad1/5 (Ser463 + Ser465)
中文名稱 磷酸化細(xì)胞信號轉(zhuǎn)導(dǎo)分子Smad-1/5抗體
別    名 Smad1 (phospho S463/465); Smad1 (phospho Ser463/465); p-Smad1 (Ser463/465); Mothers against decapentaplegic homolog 1; BSP 1; BSP1; BSP-1; Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV4-1; JV41; MAD mothers against decapentaplegic homolog 1; Mad related protein 1; MADH 1; MADH1; Madr 1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; Sma and Mad related protein 1; SMAD 1; SMAD-1; SMAD family member 1; SMAD mothers against DPP homolog 1 Drosophila; Spinal muscular atrophy distal with upper limb predominance; TGF beta signaling protein 1; Transforming growth factor beta signaling protein 1; SMAD1_HUMAN; MAD homolog 1; Mothers against DPP homolog 1; Mad-related protein 1; SMAD family member 1; Smad1; Transforming growth factor-beta-signaling protein 1.

說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞凋亡  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Smad1/5 around the phosphorylation site of Ser463/465
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

Function:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.xy-4054R    Methionine adenosyltransferase蛋氨酸腺苷轉(zhuǎn)移酶抗體
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xy-2059R    Metronidazole甲硝唑抗體
xy-3645R    MAGE-A4黑色素瘤相關(guān)抗原4抗體
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xy-4772R    MUC4粘蛋白4抗體
xy-2182R    Melamine三聚氰胺抗體
xy-3495R    Phospho-mTOR (Ser2481)磷酸化雷帕霉素靶蛋白抗體
xy-1419R    MC1 Receptor黑皮質(zhì)素-1受體抗體
xy-1445R    Motilin胃動(dòng)素抗體
xy-1582R    Mannan Binding Lectin甘露聚糖結(jié)合凝集素抗體
xy-9345R    MARCH11膜相關(guān)環(huán)指蛋白11抗體
xy-6460R    Mycobacterium tuberculosis Ag85B結(jié)核分枝桿菌Ag85B抗體
xy-5439R    phospho-MAP4(Ser1046)磷酸化微管相關(guān)蛋白4抗體
xy-5438R    phospho-MAP4(Ser941)磷酸化微管相關(guān)蛋白4抗體
xy-2689R    membrane glycoprotein E(VZV)人水痘帶狀皰疹病毒gE蛋白抗體
xy-6830R    MAGEG1黑色素瘤相關(guān)抗原G1/肝癌相關(guān)蛋白4抗體
xy-6825R    MAGEB6黑色素瘤相關(guān)抗原B6抗體
xy-6827R    MAGEC2黑色素瘤相關(guān)抗原C2抗體