細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)分子SMAD3抗體

英文名稱 Smad3
中文名稱 細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)分子SMAD3抗體
別    名 hMAD 3; hSMAD3; HSPC193; JV15 2; JV152; MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD3; MADH 3; MADH3; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; SMA and MAD related protein 3; SMAD 3; SMAD; SMAD-3; SMAD3_HUMAN.
    
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞凋亡  生長(zhǎng)因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Smad3 (31-80aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.xy-5661R    phospho-NFKB p65(Thr435)磷酸化細(xì)胞核因子抗體
xy-5662R    phospho-NFKB p65(Thr254)磷酸化細(xì)胞核因子抗體
xy-5663R    phospho-NFKB p65(Thr505)磷酸化細(xì)胞核因子抗體
xy-6167R    NET1神經(jīng)上皮細(xì)胞轉(zhuǎn)化基因1抗體
xy-6181R    Nectin 3 細(xì)胞粘附分子3抗體（脊髓灰質(zhì)炎病毒受體相關(guān)蛋白3）
xy-11524R    NHLH2螺旋環(huán)螺旋蛋白2抗體
xy-12243R    Nodal胚胎發(fā)育相關(guān)蛋白Nodal抗體
xy-12272R    NA生殖細(xì)胞增殖相關(guān)蛋白NA抗體
xy-12273R    NOBOX同源盒蛋白NOBOX抗體
xy-12247R    NAC1轉(zhuǎn)錄因子NAC1抗體
xy-7122R    NGFR神經(jīng)生長(zhǎng)因子受體抗體
xy-5517R    phospho-IKB epsilon (Ser157)磷酸化KB抑制蛋白激酶ε
xy-5519R    phospho-NRP1(Thr916)磷酸化神經(jīng)纖毛蛋白1抗體
xy-4140R    NF11型神經(jīng)纖維瘤抗體
xy-5520R    phospho-NF1(Ser2515)磷酸化1型神經(jīng)纖維瘤抗體
xy-4141R    NUDEL中心粒蛋白Nudel抗體
xy-5522R    phospho-NDEL1(Ser231)磷酸化中心粒蛋白Nudel抗體
xy-5088R    NSDHL類固醇脫氫酶樣蛋白NSDHL抗體
xy-8441R    Phospho-NFKB1(Ser373)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5521R    phospho-NF1(Ser2817)磷酸化1型神經(jīng)纖維瘤抗體
xy-8448R    Phospho-NMDAR2B (Tyr1474)磷酸化谷氨酸受體2B抗體
xy-5510R    Phospho-NFKB1 (Thr931)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5511R    Phospho-NFKB1 (Ser907)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5512R    Phospho-NFKB1 (Ser337)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5513R    Phospho-NFKB1 (Ser893)磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體
xy-5514R    Phospho-NFKBIA (Tyr42) 磷酸化IKB α抗體
xy-5515R    phospho-NFKBIA(Tyr305)磷酸化IKB alpha抗體
xy-5516R    phospho-NFATc2(Ser330)磷酸化核因子活化T細(xì)胞胞漿蛋白2抗體
xy-10156R    NOX5還原型輔酶Ⅱ氧化酶5/煙酰胺腺嘌呤二核苷酸磷酸抗體
xy-6314R    NANOS2生殖細(xì)胞增殖相關(guān)蛋白NANOS2抗體
xy-3622R    NFKB p52細(xì)胞核因子/k基因結(jié)合核因子 p52/p100抗體
xy-3723R    Phospho-NFKB2(Ser866+Ser870)磷酸化細(xì)胞核因子/k基因結(jié)合核因子p100抗體
xy-2798R    NAT2N-乙酰基轉(zhuǎn)移酶2抗體
xy-6717R    NALP2富含亮氨酸重復(fù)結(jié)構(gòu)域蛋白2抗體
xy-4636R    NR2C2孤兒核受體TAK1抗體