a-包襯蛋白抗體

英文名稱 SPECA
中文名稱 a-包襯蛋白抗體
別    名 Fodrin alpha chain; (ALPHA)II-SPECTRIN; Alpha II Spectrin; FLJ44613; Fodrin, alpha; NEAS; Non erythrocytic spectrin alpha; SPECA; Spectrin alpha chain; Spectrin alpha chain brain; Spectrin alpha non erythrocytic 1; Spectrin non erythroid alpha chain; Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Spectrin, nonerythroid, alpha subunit; Spna2; SPTA 2; SPTA2; SPTAN 1; SPTAN1; SPTA1_HUMAN.
  
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 284kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SPECA
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
a-Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.

Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Subunit:
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM and EMD. Interacts (via C-terminal spectrin repeats) with TRPC4. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1.xy-11678R    Nuclear Pore Complex Proteins核孔復(fù)合體蛋白抗體
xy-8605R    HSV 1神經(jīng)毒性因子ICP34.5（人單純皰疹病毒Ⅰ型）抗體
xy-11904R    NOTUM背板膠質(zhì)乙酰酯酶抗體
xy-11905R    NPAS3神經(jīng)細(xì)胞PAS結(jié)構(gòu)域蛋白3抗體
xy-11913R    NPDC1神經(jīng)細(xì)胞增殖和分化調(diào)控蛋白1抗體
xy-11914R    NRARPNOTCH調(diào)節(jié)錨蛋白抗體
xy-11915R    NRSN1神經(jīng)囊泡膜蛋白1抗體
xy-11916R    Neugrin突觸生長相關(guān)蛋白抗體
xy-8301R    NDUFA9NDUFA9蛋白抗體
xy-8363R    NIPA間變性淋巴瘤激酶核相互作用伴侶蛋白抗體
xy-8364R    phospho-NIPA(Ser354)磷酸化間變性淋巴瘤激酶核相互作用伴侶蛋白抗體
xy-7764R    NUSAP1核仁和紡錘體相關(guān)蛋白1抗體
xy-2054R    Nkx2.5心臟特異性同源盒轉(zhuǎn)錄因子NKX2.5抗體
xy-2975R    Noggin指(趾)關(guān)節(jié)粘連NOG蛋白抗體
xy-0700R    NSBP1核小體結(jié)合蛋白1抗體
xy-11036R    Neurexin 1軸突蛋白1(Neurexin 1α)抗體
xy-11105R    Ninjurin 1神經(jīng)損傷誘導(dǎo)蛋白1抗體
xy-11106R    Ninjurin 2神經(jīng)損傷誘導(dǎo)蛋白2抗體
xy-6261R    NEK3絲氨酸/蘇氨酸蛋白激酶Nek3抗體
xy-5732R    NEK2中心體相關(guān)蛋白激酶Nek2抗體
xy-11435R    Neurogranin神經(jīng)顆粒素抗體
xy-11428R    Neuropeptide S神經(jīng)肽S抗體
xy-11429R    Neuropeptide S神經(jīng)肽S抗體
xy-11430R    NPSR1神經(jīng)肽S受體1/G蛋白偶聯(lián)受體154抗體
xy-11420R    NMUR1G蛋白偶聯(lián)受體66/神經(jīng)調(diào)節(jié)肽U受體1抗體
xy-11421R    NMUR2G蛋白偶聯(lián)受體FM4/神經(jīng)調(diào)節(jié)肽U受體2抗體
xy-11422R    Neuropeptide S神經(jīng)肽S抗體
xy-11409R    NR0B1腎上腺發(fā)育不全相關(guān)蛋白抗體
xy-7627R    NS5ATP9丙型肝炎病毒非結(jié)構(gòu)蛋白5A反式激活蛋白9抗體
xy-7074R    NoxaNoxa蛋白抗體
xy-7073R    NME5P53誘導(dǎo)細(xì)胞凋亡抑制蛋白抗體