磷酸化磷酯酶Cβ3抗體

英文名稱 Phospho-PLC beta3 (Ser537)
中文名稱 磷酸化磷酯酶Cβ3抗體
別    名 PLC beta3 (Ser537); Phospholipase C beta 3; Phospholipase C beta 3 (phosphatidylinositol specific); PLC beta 3; PLCB3 antibody 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase beta 3; Phosphoinositide phospholipase C; PLCB3_HUMAN.

說 明 書 0.1ml  
產(chǎn)品類型 磷酸化抗體 
研究領域 免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Horse, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human PLC beta3 around the phosphorylation site of Ser537
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Subunit:
Interacts with SHANK2. Interacts with LPAR2.xy-11523R    NHLH1 + NHLH2螺旋環(huán)螺旋蛋白1+2抗體
xy-11519R    Neuronatin胚胎神經(jīng)細胞NNAT抗體
xy-13766R    NUDCD3NUDCD3蛋白抗體
xy-13776R    NKR2B4CD244自然殺傷細胞受體2B4抗體
xy-2669R    phospho-NFATc2(Ser326)磷酸化核因子活化T細胞胞漿蛋白2抗體
xy-0353R    Nonylphenol壬基酚抗體
xy-11325R    Nova2神經(jīng)腫瘤Nova2抗原抗體
xy-3571R    NCOA3類固醇受體激活蛋白3抗體
xy-1858R    Netrin 1軸突導向因子1抗體
xy-0288R    TrkB酪氨酸激酶B抗體
xy-1812R    Notch3跨膜受體蛋白Notch-3抗體
xy-6982R    Neutrophil Elastase中性粒細胞彈性蛋白酶ELANE抗體
xy-4858R    Hepatitis C Virus RNA-directed RNA polymerase丙型肝炎病毒NS4B（65kDa）抗體
xy-7671R    NGFRAP1神經(jīng)生長因子受體相關蛋白1抗體
xy-7672R    NRH2死亡結(jié)構(gòu)域蛋白NRH2抗體
xy-0046R    Neuronal thread protein AD7c-NTP神經(jīng)絲蛋白抗體
xy-0982R    phospho-NFKB p65(Ser536)磷酸化細胞核因子抗體
xy-1335R    Notch1跨膜受體蛋白Notch-1抗體
xy-3386R    Phospho-NR1D1(Ser55 + Ser59)磷酸化細胞核受體Rev-Erbα抗體
xy-10044R    Newcastle disease virus雞新城疫病毒抗體
xy-1537R    NADPH還原型輔酶Ⅱ/磷酸酰胺腺嘌呤二核苷酸抗體
xy-2012R    NIT2NIT2蛋白抗體
xy-1517R    NeuroD1神經(jīng)細胞分化因子1抗體
xy-1417R    NFAT2活化T細胞核因子1蛋白抗體
xy-2175R    NMDAR1谷氨酸受體1抗體
xy-2590R    NRSF/REST神經(jīng)元抑制蛋白抗體
xy-2304R    ARHGAP17神經(jīng)細胞發(fā)育相關調(diào)控蛋白抗體
xy-1287R    IKB alpha核因子κB抑制蛋白α抗體(IκB-α)
xy-3543R    Phospho-NFKB p65(Ser276)磷酸化細胞核因子NF-κB p65抗體
xy-3544R    Phospho-NFKB1(Ser932)磷酸化細胞核因子p50/k基因結(jié)合核因子抗體
xy-3447R    Phospho-eNOS (Ser1177)磷酸化一氧化氮合成酶3（內(nèi)皮型）抗體