滑膜細(xì)胞凋亡抑制物1抗體

英文名稱 SYVN1
中文名稱 滑膜細(xì)胞凋亡抑制物1抗體
別    名 1200010C09Rik; HRD1; KIAA1810; MGC40372; Synovial apoptosis inhibitor 1 synoviolin; Synoviolin 1 isoform b; SYVN1_HUMAN; DER3; E3 ubiquitin-protein ligase synoviolin; HMG coA reductase degradation 1 homolog; OTTHUMP00000230429; OTTHUMP00000230430; OTTHUMP00000230431; OTTHUMP00000230432; Synovial apoptosis inhibitor 1; Synoviolin 1 isoform b; SYNOVIOLIN; SYVN1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-200 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SYVN1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Function:
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.xy-6154R    RAC1+RAC2GTP結(jié)合蛋白RAC1+RAC2抗體
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xy-6174R    RAB2ras癌基因家族Rab2抗體
xy-6179R    RAB3Aras癌基因家族Rab3a抗體
xy-6177R    RAB9ras癌基因家族Rab9蛋白抗體
xy-6178R    RAB20ras癌基因家族RAB20抗體
xy-6170R    RALA+RALBRas樣蛋白A+B抗體
xy-10145R    Rad51Rad51抗體
xy-12290R    RBMY1FRNA結(jié)合蛋白片段Y染色體家族蛋白2抗體
xy-12289R    RBMY1A1RNA結(jié)合蛋白片段Y染色體家族蛋白1抗體
xy-6358R    RNA polymerase IIIRNA聚合酶III抗體
xy-10118R    phospho-Ron (Tyr1238+Tyr1239)磷酸化原癌基因c-Met相關(guān)酪氨酸激酶抗體
xy-12294R    phospho-RUNX1(Ser303)磷酸化急性髓細(xì)胞白血病1蛋白抗體
xy-7121R    Rad23DNA修復(fù)蛋白Rad23抗體
xy-12261R    RTF1組織相容性復(fù)合物RTF1抗體
xy-1574R    RRM1核糖核苷酸還原酶1抗體
xy-9232R    RNF167環(huán)指蛋白167抗體
xy-2214R    Resistin抵抗素抗體
xy-3560R    RASGRF1Ras特異性鳥嘌呤核苷酸釋放因子1
xy-3554R    Rsk2核糖體S6激酶RSK2抗體
xy-3647R    RACK1受體激活蛋白激酶C1抗體
xy-3863R    ROR Gamma孤兒核受體抗體
xy-9163R    RNF17環(huán)指蛋白17抗體
xy-1264R    RSV呼吸道合胞病毒抗體
xy-4179R    RAD9細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-5642R    phospho-RAD9(Ser272)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-5655R    phospho-RAD9(Ser336)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-5656R    phospho-RAD9(Ser375)磷酸化細(xì)胞周期檢查控制蛋白質(zhì)抗體
xy-1483R    RBBP6增殖潛能相關(guān)蛋白抗體
xy-1480R    Rho CRhoC抗體