血影蛋白A鏈非紅細(xì)胞型/收縮蛋白/Spectrin α抗體

英文名稱 Spectrin alpha chain, non-erythrocytic 1
中文名稱 血影蛋白A鏈非紅細(xì)胞型/收縮蛋白/Spectrin α抗體
別    名 SPTN1_HUMAN; Alpha Fodrin; Spectrin-Alpha; SPEC; Spectrin, alpha, non-erythrocy tic 1 variant; Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit; SPTAN1; SPTA2; alpha-II spectrin; spectrin, non-erythroid alpha chain; alpha-fodrin; spectrin, non-erythroid alpha subunit; spectrin alpha chain, non-erythrocytic 1; EIEE5; NEAS.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 心血管  細(xì)胞生物  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, 
產(chǎn)品應(yīng)用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 272kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Spectrin alpha chain, non-erythrocytic 1 (20-65aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Function:
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Subunit:
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts with isoform 1 of ACP1. Interacts with CALM and EMD. Interacts (via C-terminal spectrin repeats) with TRPC4. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1.xy-0447R    Thyroid peroxidase甲狀腺過氧化物酶抗體
xy-1202R    TRADD腫瘤壞死因子受體1相關(guān)死亡域蛋白抗體
xy-1217R    TSARG3生精細(xì)胞凋亡相關(guān)基因3抗體
xy-0339R    T3三碘甲狀腺素T3抗體
xy-0632R    Thioster-containing protein 1按蚊硫酯包含蛋白-1抗體
xy-1909R    omerase Binding Protein, P23端粒酶結(jié)合蛋白P23抗體
xy-1923R    TSARG6生精細(xì)胞凋亡相關(guān)基因6抗體
xy-0176R    Trk C酪氨酸激酶C抗體(神經(jīng)生長因子受體的一種)
xy-1243R    Trop-2原肌球蛋白抗體
xy-0460R    TSHR促甲狀腺素受體抗體
xy-0206R    TSHR (CT)促甲狀腺素受體抗體（C端）
xy-3439R    Phospho-TAK1(Thr184 + Thr187)磷酸化轉(zhuǎn)化生長因子β活化激酶1
xy-3440R    Phospho-TBK1 (Ser172)磷酸化NF-κB活化激酶抗體
xy-3586R    Tuberin馬鈴薯球蛋白(結(jié)節(jié)性硬化)抗體
xy-3441R    Phospho-Tuberin (Ser1387)磷酸化馬鈴薯球蛋白(結(jié)節(jié)性硬化)抗體
xy-3442R    Phospho-Tuberin(Ser939)磷酸化馬鈴薯球蛋白(結(jié)節(jié)性硬化)抗體
xy-3443R    Phospho-Tuberin(Tyr1571)磷酸化馬鈴薯球蛋白(結(jié)節(jié)性硬化)抗體
xy-3444R    Phospho-TSC2 (Thr1462)磷酸化馬鈴薯球蛋白(結(jié)節(jié)性硬化)抗體
xy-3445R    Phospho-Tuberin (Thr927)磷酸化馬鈴薯球蛋白(結(jié)節(jié)性硬化)抗體
xy-3446R    phospho-Tau protein(Ser396)磷酸化微管相關(guān)蛋白抗體
xy-3587R    TNK1非受體型酪氨酸蛋白激酶Tnk1抗體
xy-3450R    Phospho-TNK1 (Tyr277)磷酸化非受體型酪氨酸蛋白激酶Tnk1抗體
xy-3451R    phospho-TOPO II Alpha (Ser1106)磷酸化DNA拓普西異構(gòu)酶Ⅱ抗體
xy-3588R    TORC1環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白轉(zhuǎn)錄共激活因子TORC1抗體
xy-3453R    Phospho-Torc1 (Ser151)磷酸化CREB轉(zhuǎn)錄共激活因子TORC1抗體
xy-3590R    TORC2CREB轉(zhuǎn)錄共激活因子TORC2抗體
xy-0093R    TNF beta腫瘤壞死因子β抗體（TNFβ）
xy-1280R    TCF7L2轉(zhuǎn)錄因子7類似物2抗體
xy-0507R    TBX2血栓素B2(一種新發(fā)現(xiàn)的抑癌基因)抗體