5-脂氧合酶抗體

英文名稱 5 lipoxygenase
中文名稱 5-脂氧合酶抗體
別    名 5-lipoxygenase; 5-LOX; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonic acid 5 lipoxygenase; Leukotriene A4 synthase; LOG 5; LOG5; MGC163204; LOX5_HUMAN.
   
說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 78kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human 5 Lipoxygenase
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹 background:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Function:
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Subunit:
Interacts with ALOX5AP and LTC4S.xy-6104R    SHPRH組蛋白連接作用蛋白抗體
xy-6105R    SIRT3線粒體乙酰化酶3抗體
xy-6106R    SLC5A8鈉碘轉(zhuǎn)運體蛋白8抗體
xy-6099R    SASH1腫瘤抑制基因PEPE1抗體
xy-6100R    SESN3Sestrin3抗體
xy-6108R    SMYD4組蛋白甲基轉(zhuǎn)移酶SMYD4抗體
xy-4230R    mSin3A同源轉(zhuǎn)錄調(diào)節(jié)蛋白Sin3A抗體
xy-4254R    STAT5b信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5b抗體
xy-5703R    phospho-STAT5b(Ser731) 磷酸化信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5b抗體
xy-3858R    SH2D2A血管內(nèi)皮生長因子受體相關(guān)蛋白抗體
xy-4031R    SLC9A9鈉氫通道蛋白9家族A9抗體
xy-4035R    SENP3類泛素蛋白3抗體
xy-2743R    SLIT2/Slil3神經(jīng)遷移蛋白Slit2/3抗體
xy-2801R    Smoothened跨膜蛋白Smoothened抗體
xy-2805R    Stanniocalcin 1斯鈣素抗體
xy-6399R    SIPA1信號誘導(dǎo)增殖相關(guān)蛋白1抗體
xy-6899R    STK40絲氨酸/蘇氨酸蛋白激酶40抗體
xy-3753R    SCG10神經(jīng)生長相關(guān)蛋白SCG10抗體
xy-3759R    S100A4S100A4抗體
xy-3919R    STARD5促黃體激素誘導(dǎo)蛋白5抗體
xy-3752R    Sca1T淋巴細(xì)胞激活蛋白抗體
xy-3388R    Phospho-RPS6 (Ser235+Ser236)磷酸化S6核糖體蛋白抗體
xy-3392R    Phospho-MEK4 (Ser257)磷酸化絲裂原活化蛋白激酶激酶4抗體
xy-3693R    Phospho-MEK4 (Thr261)磷酸化絲裂原活化蛋白激酶激酶4抗體
xy-3394R    Phospho-MEK4 (Ser257 + Thr261)磷酸化絲裂原活化蛋白激酶激酶4抗體
xy-4904R    SGK1糖皮質(zhì)激素調(diào)節(jié)激酶1抗體
xy-3340R    Phospho-PLC beta3 (Ser537)磷酸化磷酯酶Cβ3抗體
xy-3407R    Phospho-SMC1(Ser957)磷酸化染色體結(jié)構(gòu)維持蛋白質(zhì)１抗體
xy-0478R    SLC6A19鉀依賴鈉鈣交換蛋白6抗體
xy-9596R    SPAG17精子相關(guān)抗原17抗體
xy-1729R    phospho-Syndecan 4(Ser179)磷酸化多配體聚糖4(Ser179)抗體