鋅指蛋白259抗體

英文名稱 ZNF259/ZPR1
中文名稱 鋅指蛋白259抗體
別    名 MGC110983; Zinc finger protein 259; Zinc finger protein ZPR1; ZNF 259; ZNF259; ZPR1; ZPR1_HUMAN.

說(shuō) 明 書 0.2ml  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  鋅指蛋白  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 51kDa
細(xì)胞定位 細(xì)胞核 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF259/ZPR1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
ZPR1 is a zinc finger-containing protein that is capable of binding to the intracellular tyrosine kinase domain of the epidermal growth factor receptor. Stimulation of mammalian cells with epidermal growth factor reduces ZPR1 affinity for the EGFR and leads to an accumulation of the protein in the nucleus. The ZPR1 zinc finger is necessary for its association with the EGFR.

Function:
Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H2O(2)-induced neuronal cell death.

Subunit:
Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum By similarity. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and EGFR kinase activity. May also bind to the PDGFR receptor.xy-0289xy    neurofasciu-155神經(jīng)束蛋白-155
xy-0067xy    NGF- Beta神經(jīng)生長(zhǎng)因子-β(多肽片斷抗原)
xy-1707xy    Ang I/AT1(Angiotensin I)血管緊張素I抗原
xy-0161xy    NGF-R(p75NTR)神經(jīng)生長(zhǎng)因子受體（抗原）
xy-0630xy    AT1R(Angiotensin II Type 1 Receptor)血管緊張素Ⅱ-1型受體抗原
xy-2097xy    AT1R/AGTR1(Angiotensin II Type 1 Receptor)血管緊張素Ⅱ-1型受體抗原
xy-0074xy    NIK，NF-kappaB-Inducing KinaseNFkB誘導(dǎo)的激酶（抗原）
xy-0517xy    ATF1 (Activating Transcription Factor1)活化復(fù)制因子1
xy-11422xy    NPS/Neuropeptide S神經(jīng)肽S
xy-0070xy    NKB (Neurokinins B)神經(jīng)激肽B（抗原）
xy-0518xy    ATF2 (Activating Transcription Factor2)活化復(fù)制因子2（多肽）
xy-1648xy    phospho-ATF2(pSer490/pSer498)磷酸化活化復(fù)制因子2抗原
xy-0166xy    NKR ； Neurokin B receptor (Neuromedin K receptor; NK-4 receptor)神經(jīng)激肽-B受體（抗原）
xy-0519xy    ATF3 (Activating Transcription Factor3)活化轉(zhuǎn)錄因子3抗原
xy-1370xy    ATM(ataxia angiectasia mutated)毛細(xì)血管擴(kuò)張性共濟(jì)失調(diào)癥突變蛋白抗原
xy-1634xy    ATF6(activating transcription factor 6)活化轉(zhuǎn)錄因子6抗原
xy-1152xy    ATP1b2/Na+K+ ATPase(ATPase, Na+/K+ transporting, beta 2 polypeptide)鈉鉀ATP酶通道蛋白抗原
xy-2436xy    Kir6.2 peptideATP敏感性鉀通道亞基kir6.2抗原
xy-1705xy    AVPR2(arginine vasopressin receptor 2)精氨酸加壓素受體2抗原
xy-2445xy    Aurora B極光激酶B抗原
xy-0075xy    Nociceptin孤菲肽（痛敏肽）（抗原）
xy-1103xy    B7-H1/PDL1/CD274(programmed death ligand 1)程序性死亡配體1（多肽）
xy-0181xy    Nociceptin receptor孤菲肽受體（痛敏肽受體）（抗原）
xy-0134xy    Nogo-A軸索過(guò)度生長(zhǎng)抑制因子-A（抗原）
xy-0129xy    Nogo R軸索過(guò)度生長(zhǎng)抑制因子受體（多肽抗原）
xy-0892xy    Bad (BCL-xL/BCL-2-associated death promoter)相關(guān)死亡促進(jìn)因子Bad抗原
xy-1304xy    Bad (BCL-xL/BCL-2-associated death promoter)相關(guān)死亡促進(jìn)因子Bad抗原
xy-0893xy    phospho-BAD(pSer128)磷酸化相關(guān)死亡促進(jìn)因子抗體
xy-1284xy    Bak(BCL2 homologous antagonist/killer)Bcl-2同源拮抗劑Bak（多肽）
xy-0156xy    NOS-1(bNOS:neuronal NOS:nNOS:Nitric Oxide synthase-1)一氧化氮合成酶-1（抗原）
xy-0162xy    NOS-2 (iNOS) Nitric Oxide Synthase,Inducible一氧化氮合成酶-2（抗原）
xy-0911xy    Batroxobin蛇毒巴曲酶抗原
xy-0163xy    NOS-3 (eNOS) endotheli cell NOS一氧化氮合成酶-3（抗原）