X射線修復(fù)交叉互補(bǔ)蛋白抗體

英文名稱 XRCC1
中文名稱 X射線修復(fù)交叉互補(bǔ)蛋白抗體
別    名 DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray repair complementing defective repair in chinese hamster cells 1; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair cross complementing protein 1; RCC; X ray repair, complementing defective, repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN; XRCC 1.

說 明 書 0.1ml  0.2ml  
研究領(lǐng)域 腫瘤  染色質(zhì)和核信號(hào)  新陳代謝  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human XRCC1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsalite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. In testis XRCC1 is expressed at high levels.

Function:
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

Subunit:
Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. xy-1997R    NCX2鈉鈣交換蛋白2抗體
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xy-2401R    Nebulin伴肌動(dòng)蛋白抗體
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xy-3512R    NuMA核有絲分裂器NuMA蛋白抗體
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xy-3307R    NMDAR2B谷氨酸受體2B抗體
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xy-3309R    Phospho-NPM (Thr95)磷酸化核仁磷酸蛋白抗體
xy-3310R    Phospho-NPM (Thr199)磷酸化核仁磷酸蛋白抗體
xy-1156R    IKB beta核因子κB抑制蛋白β抗體
xy-3305R    Phospho-NMDAR2A (Tyr1325)磷酸化谷氨酸受體2A抗體
xy-1801R    NPTN間質(zhì)細(xì)胞衍化因子受體1抗體
xy-11918R    Neuro D2神經(jīng)細(xì)胞分化因子2抗體
xy-11678R    Nuclear Pore Complex Proteins核孔復(fù)合體蛋白抗體
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xy-11915R    NRSN1神經(jīng)囊泡膜蛋白1抗體
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