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中英文說明丨艾美捷PD1抗體(BXC-BE0146)

時(shí)間:2023/5/6閱讀:232
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PD-1/PD-L1 has become a research hotspot in tumor immunotherapy in recent years. Tumor cells recruit immunosuppressive cells and cytokines by overexpressing PD-1/PD-L1, reduce the Antigenicity of tumor cells, and tilt the balance of immune microenvironment from steady state to immunosuppression. This process is called immune editing.

Immune editing includes three processes: clearing, balancing, and escaping. Tumor cells ultimately evade the anti-tumor effects of the body's immune system through immune editing, forming clinically detectable tumors.

In recent years, research related to PD-1 antibodies has emerged, which may become a major anti-tumor tool.

 

Background of PD1 antibody (BXC-BE0146):

The InVivoMAb anti mouse PD-1 (CD279):

Research fields: cancer biology, immune checkpoint proteins, immunology;

Clone number: RMP1-14;

Antigen: PD-1;

Host source: rats;

Antibody subtype: IgG2a, κ;

Molecular weight: 150 kDa;

Recommended homotypic control: InVivoMAb anti mouse PD-1 (CD279) product number: BE0089;

Concentration: usually between 4 and 11 mg/ml depending on the batch;

Recommended dilution buffer: InVivoPure pH 7.0 dilution buffer, product number: IP0070;

 

艾美捷 PD1抗體(BXC-BE0146)背景:

該InVivoMAb 抗小鼠 PD-1 (CD279)(InVivoMAb anti-mouse PD-1 (CD279)):

研究領(lǐng)域:癌癥生物學(xué), 免疫檢查點(diǎn)蛋白, 免疫學(xué);

克隆號(hào):RMP1-14;

抗原:PD-1;

宿主來源:大鼠;

抗體亞型:IgG2a, κ;

分子量:150 kDa;

推薦同型對(duì)照:InVivoMAb 抗小鼠 PD-1 (CD279)貨號(hào)為:BE0089;

濃度:因批次可能不同,通常在4-11 mg/ml之間;

推薦的稀釋緩沖液:InVivoPure pH 7.0 稀釋緩沖液,貨號(hào):IP0070;

638189870923105604903.png

PD1抗體(BXC-BE0146)相關(guān)研究:

體內(nèi)單克隆抗體抗小鼠PD-1 (CD279) (克隆J43)

體內(nèi)單克隆抗體抗人類PD-1 (CD279) (克隆J116)

體內(nèi)單克隆抗體抗人類PD-1 (CD279) (克隆J110)

體內(nèi)單克隆抗體抗小鼠PD-1 (CD279) (克隆29F.1A12™)

體內(nèi)加上抗小鼠PD-1(CD279)(克隆J43)

體內(nèi)加上抗小鼠PD-1(CD279)(克隆29F.1A12™)

RecombiMAb 抗小鼠 PD-1 (CD279) (D265A) (克隆 RMP1-14-CP151)

RecombiMAb抗小鼠PD-1 (CD279) (克隆RMP1-14-CP157)

RecombiMAb抗小鼠PD-1 (CD279) (克隆RMP1-14-CP162)

體內(nèi)SIM抗人類PD-1(納武利尤單抗生物類似藥)

體內(nèi)加上抗小鼠PD-1(CD279)(克隆29F.1A12™)

體內(nèi)SIM抗人PD-1(帕博利珠單抗生物類似藥)(克隆帕博利珠單抗)


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