MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)。

Anastrozole

CAS No. : 120511-73-1

MCE 國(guó)際站：Anastrozole

產(chǎn)品活性：Anastrozole 是一種選擇性的芳香酶 (aromatase) 抑制劑，抑制胎盤(pán)芳香化酶，IC₅₀ 為 15 nM。

研究領(lǐng)域：Metabolic Enzyme/Protease

作用靶點(diǎn)：Cytochrome P450

In Vitro: Anastrozole is a comparatively simple, achiral benzyltriazole derivative, that inhibits human placental aromatase with an IC₅₀ of 15 nM. In the same assay it is 200 times as potent as aminoglutethimide (AG), twice as potent as 4-OHA and one third as potent as Fadrozole.

In Vivo: Groups of eight immature (22-day-old) female rats are given androstenedione (AD) (30 mg/kg) in arachis oil s.c. daily for3 days with or without various doses of Anastrozole p.o. on day 4 the uteri are dissected, blotted and weighed. An oral dose of 0.1 mg/kg of Anastrozole given on day 2 or day 3 of the cycle completely blocked ovulation. At the same daily dosage (0.1 mg/kg), Anastrozole completely extinguished the uterotrophic activity of exogenous AD in immature rats. In male pigtailed monkeys, twice-daily oral treatment with 0.1 mg/kg and above of Anastrozole reduced circulating oestradiol concentrations by 50-60%.

相關(guān)產(chǎn)品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  FDA-Approved Drug Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Targeted Therapy Drug Library   |  Mitochondria-Targeted Compound Library  |  Rare Diseases Drug Library  |  FDA-Approved Anticancer Drug Library  |  Human Metabolite Library  |  Off-patent Drug Library  |  Highly Selective Inhibitors Library  |  Verapamil  |  Apigenin  |  Fenofibrate  |  Chlorpromazine hydrochloride  |  Ketoconazole  |  1-Aminobenzotriazole  |  Letrozole  |  Abiraterone  |  Itraconazole  |  Cepharanthine  |  Quinidine (15% dihydroquinidine)  |  Diosmetin  |  Clarithromycin  |  Naringin  |  Gemfibrozil 1-O-β-glucuronide  |  Atovaquone  |  Fomepizole  |  Talarozole  |  Cobicistat  |  Salvianolic acid C  |  Hypericin  |  Methoxsalen  |  Sulfaphenazole  |  (S)-Mephenytoin  |  Furafylline  |  Gemfibrozil  |  HET0016

熱門(mén)產(chǎn)品線：重組蛋白  |  化合物庫(kù)  |  天然產(chǎn)物  |  熒光染料  |  PROTAC  |  同位素標(biāo)記物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds