PD-1/PD-L1 has become a research hotspot in tumor immunotherapy in recent years. Tumor cells recruit immunosuppressive cells and cytokines by overexpressing PD-1/PD-L1, reduce the Antigenicity of tumor cells, and tilt the balance of immune microenvironment from steady state to immunosuppression. This process is called immune editing.
Immune editing includes three processes: clearing, balancing, and escaping. Tumor cells ultimately evade the anti-tumor effects of the body's immune system through immune editing, forming clinically detectable tumors.
In recent years, research related to PD-1 antibodies has emerged, which may become a major anti-tumor tool.
Background of PD1 antibody (BXC-BE0146):
The InVivoMAb anti mouse PD-1 (CD279):
Research fields: cancer biology, immune checkpoint proteins, immunology;
Clone number: RMP1-14;
Antigen: PD-1;
Host source: rats;
Antibody subtype: IgG2a, κ;
Molecular weight: 150 kDa;
Recommended homotypic control: InVivoMAb anti mouse PD-1 (CD279) product number: BE0089;
Concentration: usually between 4 and 11 mg/ml depending on the batch;
Recommended dilution buffer: InVivoPure pH 7.0 dilution buffer, product number: IP0070;
艾美捷 PD1抗體(BXC-BE0146)背景:
該InVivoMAb 抗小鼠 PD-1 (CD279)(InVivoMAb anti-mouse PD-1 (CD279)):
研究領(lǐng)域:癌癥生物學(xué), 免疫檢查點(diǎn)蛋白, 免疫學(xué);
克隆號(hào):RMP1-14;
抗原:PD-1;
宿主來源:大鼠;
抗體亞型:IgG2a, κ;
分子量:150 kDa;
推薦同型對(duì)照:InVivoMAb 抗小鼠 PD-1 (CD279)貨號(hào)為:BE0089;
濃度:因批次可能不同,通常在4-11 mg/ml之間;
推薦的稀釋緩沖液:InVivoPure pH 7.0 稀釋緩沖液,貨號(hào):IP0070;
PD1抗體(BXC-BE0146)相關(guān)研究:
體內(nèi)單克隆抗體抗小鼠PD-1 (CD279) (克隆J43)
體內(nèi)單克隆抗體抗人類PD-1 (CD279) (克隆J116)
體內(nèi)單克隆抗體抗人類PD-1 (CD279) (克隆J110)
體內(nèi)單克隆抗體抗小鼠PD-1 (CD279) (克隆29F.1A12™)
體內(nèi)加上抗小鼠PD-1(CD279)(克隆J43)
體內(nèi)加上抗小鼠PD-1(CD279)(克隆29F.1A12™)
RecombiMAb 抗小鼠 PD-1 (CD279) (D265A) (克隆 RMP1-14-CP151)
RecombiMAb抗小鼠PD-1 (CD279) (克隆RMP1-14-CP157)
RecombiMAb抗小鼠PD-1 (CD279) (克隆RMP1-14-CP162)
體內(nèi)SIM抗人類PD-1(納武利尤單抗生物類似藥)
體內(nèi)加上抗小鼠PD-1(CD279)(克隆29F.1A12™)
體內(nèi)SIM抗人PD-1(帕博利珠單抗生物類似藥)(克隆帕博利珠單抗)
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