產(chǎn)品名稱：Irbesartan
產(chǎn)品價(jià)格：2212
產(chǎn)    地：Cayman
產(chǎn)品貨號(hào)：11952
產(chǎn)品規(guī)格：50 mg
產(chǎn)品說(shuō)明：
Synonyms:SR 47436 BMS 186295 Aprovel Karvea
Formal Name2-?butyl-?3-?[[2'-?（2H-?tetrazol-?5?yl）[1,?1'-?biphenyl]-?4-?yl]methyl]-?1,?3-?diazaspiro[4.4]non-?1-?en-?4-?one
CAS Number138402-11-6
Molecular FormulaC25H28N6O
Formula Weight428.5
FormulationA crystalline solid
Purity≥98%
Stability2 years
Storage-20°C
Shipping Room temperature in continental US; may vary elsewhere
Description
Angiotensin II receptor blockers （ARBs） act as cardioprotective agents that are effective in hypertension, left ventricular hypertrophy, postmyocardial infarction, and heart failure.1 Irbesartan is an ARB with a high affinity for the AT1 receptor （Ki = 2.7 nM） and exceptionally high bioavailability （60-80%）.2,3 It is an insurmountable antagonist of AT1, as its antagonism of this receptor cannot be overcome by increasing concentrations of angiotensin II.4 effectively reduces blood pressure alone but may also be used in combination with a diuretic, such as hydrochlorothiazide.3,5 As angiotensin II contributes in diverse ways to endothelial dysfunction, irbesartan and other ARBs directly protect the vascular endothelium.6,7 Other pathologies, including diabetes and kidney disease, also benefit from the cardiovascular and endothelial protective actions of ARBs like irbesartan.