11CHA001Charybdotoxin /ChTx
【簡單介紹】
品牌 | Smartox |
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【詳細說明】
Charybdotoxin /ChTx
KCa2+ channel blocker(KCa2+ 通道阻斷劑)
Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Ca2+ activated K+ channels KCa1.1 in nanomolar concentrations (IC50~ 3 nM). This blockade causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of 2.1 nM. ChTX also blocksKCa3.1 (IC50 5 nM), Kv1.2 (IC50 14 nM), Kv1.3 (IC50 2.6 nM) and Kv1.6 (IC50 2 nM) channels.
ChTx技術資料
氨基酸序列:
H-Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys28-Met-Asn-Lys-Lys-Cys33-Arg-Cys35-Tyr-Ser-OH
二硫鍵:Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35
長度(aa): 37
分子式:C176H277N57O55S7
分子量: 4295.90 Da
外觀:White lyophilized solid
可溶性: water and saline buffer
CAS 號:95751-30-7
來源:Synthetic
純度:> 97%
產(chǎn)品信息
11CHA001-00050 | Charybdotoxin | 0.05mg |
11CHA001-00100 | Charybdotoxin | 0.1mg |
11CHA001-00500 | Charybdotoxin | 0.5mg |
11CHA001-01000 | Charybdotoxin | 1mg |
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- 11CHA001Charybdotoxin /ChTx
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